Methylformamide

The location and shape of the entire electrocapillary curve are affected if the general nature of the medium is changed. Fawcett and co-workers (see Ref. 126) have used nonaqueous media such as methanol, V-methylformamide, and propylene carbonate. In earlier studies, electrocapillaiy curves were obtained for O.OIA/ hydrochloric acid in mixed water-ethanol media of various compositions [117, 118]. The surface adsorption of methanol, obtained from... 

The idea is to have everything in place before the oxygen is applied. So, lOOg of safrole is in the addition funnel and stirring around in the reaction flask are 10.6g of PdCU, 60g CuCI and 500mL of aqueous dimethylformamide (made by mixing 62.5mL dH20 and 437,5mL DMF). Dimethylformamide (DMF) is not the same as the watched chemical known as N-methylformamide. 

A solution of 45 g of triphenyl phosphite methiodide in 100 ml of dry di-methylformamide was heated at 100°C and 0.08 mol of the acetylenic alcohol (commercially available) was added in 2 min. After stirring for 30 min at 100°C the mixture was cooled. The flask was equipped for vacuum distillation. On the flask were placed a 25-cm Vigreux column and two stoppers and the column was connected with a condenser and a receiver. The DMF and the iodoallene distilled between... 

The reduction of l,4-diene-3,20-diones also proceeds more rapidly at the 20-position, at least in methanol, ethanoF and methanol-di-methylformamide. Under mild conditions, the 11-one of a l,4-diene-3,l 1-dione is reduced selectively by NaBH4, but this reaction is better done by Li[OC(CH3)3]3AlH (see below). The reaction of a 4,6-diene-3,20-dione with NaBH4 in methanol for 2 hours at 20° gives the 3j5-hydroxy-20-one. ... 

The reactions of A -steroids with nitrosyl fluoride parallel those of their A -isomers. Thus, 17 -acetoxyandrost-4-ene (37) is converted to the nitrimine (38), in 67 % yield and thence to the 4-ketone (39), which can be dehydrofluorinated to the A -4-ketone (40) with lithium bromide in di-methylformamide. In the corresponding 19-nor series the nitroso dimer is also formed. 

Treatment of 1-hydroxy-iVb-trifluoroacetyltryptamine (48), which is readily available in three steps from tryptamine (259, Scheme 40), with MsCl in THF in the presence of indole (3 mol eq) and EtsN produces l-trifluoroacetyl-1,2,3,8-tetrahydropyrrolo[2,3-(j]indole (49c, 25%), l-trifluoroacetyl-3a-(4-chlorobutoxy)-l,2,3,3a,8,8a-hexahydropyrrolo[2,3-(j]indole (52c, 6%), iVb-trifluoroacetyl-6-mesyloxytryptamine (50c, 8%), 3a-(indol-2-yl)- (260, 5%), and 3a-(indol-3-yl)-l-trifluoroacetyl-l,2,3,3a,8,8a-hexahydropyrrolo[2,3-(j]indole (261, 12%). In this reaction, solvent plays an important role. Among the tested solvents such as benzene, CHCI3, 1,2-dichloroethane, THF, DMF, CH3CN, and iV-methylformamide, CHCI3 is found to be the solvent of choice to provide a 21% yield of 261. The use of excess indole (10 mol eq) further raises the yield to 30%. 

Dehydration of N-methylformamide by />-toluenesulfonyl chloride quinoline to form methyl isocyanide, 46,75... 

Methoxymethoxy)(phenyl)methylcesium has been generated at room temperature in di-methylformamide by fluoride-induced desilylation from optically active benzyltrimethylsilane and trapped in situ by 2-cyclohexenone with 89% racemization41. 

Procedure A 0.05N soln of KOH in iso-Pr ale is prepd and standardized with primary std benzoic ac. A 0.4g sample is weighed to the nearest O.lmg into a 250ml erlenmeyer flask. 75ml of a 50/50 mixt by vol of iso-Pr ale di-methylformamide added, the flask swept with N, iiiii of the indicator soln added, and the sum... 

Mix the hydrogenated product with 20 ml thionyl chloride and 0.5 g di-methylformamide and reflux the resulting solution with agitation under a nitrogen atmosphere at 80-85°C. Optimum reaction time for C18 alkanesulfonate is 45 min longer times produce oxidized materials. 

DMSO, dimelhyltulfoxide. DMF, dimethyl fomumiiie. PC, propylene carbonate. AN. acetonitrile. AC. acetone NMF, N methylformamide... 

The Hg/V-methylformamide (NMF) interface has been studied by the capacitance method as a function of temperature.108,294,303 The potential of Hg was measured with respect to the reference electrode Ag/0.05 M AgC104 + 0.05 M NaC104 in water. The specific adsorption of C104 was found to be negligible at a < 6 /iC cm"2. The experimental capacitance data have been discussed in terms of the four-state model,121,291,294 which assumes the presence of both monomers and clusters in the surface layer of the solvent. The model has been found to describe the experimental picture qualitatively but not quantitatively. This is related to the fact that NMF is a strongly associated solvent.108,109,294,303... 

Ga, In(Ga), Tl(Ga), and Hg in A-methylformamide + NaC104 solutions have been studied by the impedance method.359 The capacitance of the electrical double-layer for all electrodes in the frequency range 200 Hz < v < 5000 Hz was independent of v. The values of Ea=Q were usually... 

A related pyranopyrimidine 63 has been prepared by the irradiation of 1,3-dimethylbarbituric acid 61, a methylene active nitrile 47a and N,N-di-methylformamide dimethylacetal 45 [77]. After initial formation of the enam-... 

The same group found that heteroaromatic halides can be smoothly phenylated using NaBPh4 as the transmetallating agent and ligand-free Pd(OAc)2 as a catalyst with water or AT-methylformamide (NMF) as the solvent (Scheme 21) [39], The experiments were all performed using power control. 

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