2.3- Methylenedioxyphenylacetic acid,

Lithium aluminum hydride 3,4-Methylenedioxyphenylacetic acid Phosphorus tribromide... 

Methylenedioxyphenylacetic acid (18.0 g) was added portion wise over 30 minutes to a stirred, ice-cooled suspension of lithium aluminium hydride (4.0 g) in ether (400 ml) and the mixture was stirred at temperature for two hours, quenched by the cautious addition of saturated aqueous ammonium chloride solution and filtered. The filtrate was washed with 10% aqueous sodium carbonate solution, dried over magnesium sulfate and evaporated to give the title compound as a pale yellow oil (15.01 g, 90%), which was characterized by its tH-NMR spectrum. 

This starting material is prepared in three steps from commercially available (from Research Organic/Inorganic Chemical Corp., Belleville, NJ) 3,4-methylenedioxyphenylacetic acid according to well-established procedures that have been applied to similar compounds. First, 16.0 g (88.8 mmol) of the acid, recrystallized from chloroform, is dissolved in 50 mL of tetra-hydrofuran, and the solution is added to a suspension of 5.98 g (158 mmol) of lithium aluminum hydride powder in 225 ml of distilled diethyl ether (Note 3) at 0°C. [Caution Lithium aluminum hydride ie very sensitive to mechanical shock, and very reactive towards moisture and other protic substances its dust is very irritating to skin and mucous membranes. It should not be allowed to come into contact with metallic species or apparatus, including metal... 

Phenyl-3,4-dihydro-6,7-methyl enedloxyi soquinol 1ne l,3-Dioxolo[4,5-g ]iso-quinoline, 7,8-dihydro-5-phenyl- (10) (55507-10-3) 3,4-Methylenedioxyphenylacetic acid Acetic acid, [3,4-(methylene-dioxy)phenyl]- (8) l,3-Benzodioxole-5-acetic acid (9) (2861-28-1)... 

Homopiperonylic Acid 3,4-Methylenedioxyphenylacetic Acid Preparation from Safrol... 

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