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Methylation of Aromatics Investigated in Micro Reactors

3 Methylation of Aromatics Investigated in Micro Reactors Organic synthesus 89 [OS 89] Methylation of a 1,3,4-substituted benzene [Pg.555]

4-substituted benzene is reacted with an N,N-disubstituted-N -methyl-amine resulting in transfer of the methyl group to the 2-position of the aromatic ring, thereby creating a crowded 1,2,3,4-substituted aromatic [127]. No details on the nature of the substituents and the presence of a solvent are given, as the process is proprietary. The temperature in the micro reactor was set to 0 °C. [Pg.555]

Conversion/selectivity/yield - benchmarking to industrial process [Pg.556]




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Aromatics, methylation

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