9-Methyladenine, platinum complex

A triplanar platinum adenine complex [Pt3(NH3)38(9-methyladenine)2](N03)6 2H20 is reported. The 2(NH3)3Pt(II) residue is bound to 9-methyladenine via N-7 and a cA-(NH3)2Pt(II) unit is bound through N-l. The two adenine rings are oriented head to head in the solid state whilst in solution equilibrium between two rotamers (head to head and head to tail) exists <93iCA3i>. 

It has been demonstrated that the tran5 -[(NH3)2PtCl] adduct of 1-methylcytosine, bound via N-3, can form crosslinks with either 9-ethylguanine or 9-methyladenine as a result of Cl substitution by purine N-7 atoms. Additional H-bonds between exocyclic groups of cross-linked nucleic acid bases provide additional stabihzation of the individual complexes (Figure 13d). Binding of the related complex [(NH3)2Pt(N-3-cytosine)Cl]+ with d(GG) leads to the formation of a major product in which the platinum is bound only to N-7 of the 5 -nucleotide. ... 

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