Methyl trifluorinated

In contrast to the toxicity of these fluorinated oxygen and nitrogen-containing compounds, the products from trifluorinated methyl ketones and amines are reported to have low acute toxicities 62). The fluorocarbons are insoluble in water, alcohol, and hydrocarbons 38). 

Trifluoro-ABA (28) was synthesized from the methyl ester of trifluorinated P-ionylideneacetic acid, which was prepared by the method reported for the synthesis of 16,16,16-trifluororetinal [71,72], More... 

The increased lipophilicity (n), and a superior metabolic stability compared with the methyl analogue, often leads to an improved activity profile. Mono-fluorination and trifluorination of saturated aliphatic groups normally decrease lipophilicity, whereas higher fluoroalkyl groups (perfluoroalkyl groups) are introduced mainly to increase the lipophilicity [61], as recently shown for the 4 -perfluoro-iso-propyl-2-methyl-phenyl-amide fragment (4 -position halogen < fluoroalkoxy < CFj < C2 4-fluoroalkyl) in flubendiamide 54 ISO-proposed Nihon Nohyaku Co., Ltd./Bayer CropScience) (for more details see Chapter 31). 

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