2 METHYL-3-PHENYLPROPIONAL

ALDEHYDES FROM ALLYLIC ALCOHOLS AND PHENYLPALLADIUM ACETATE 2-METHYL- 3-PHENYLPROPIONAL-DEHYDE, 51, 17 ALDEHYDES FROM AROMATIC NITRILES p-FORMYLBENZENE-SULFONAMIDE, 51, 20 ALDEHYDES FROM 2-BENZYL-4,4,6-TRIMETHYL—5,6-DIHYDRO-l, 3-(4H)-OXAZINE 1-PHENYLCYCLO-PENTANECARBOXYALDEHYDE, 51,... [Pg.54]

CHLOROCYCLOBUTANE, 51, 106 Mesitylene, cyanation, 50, 54 METHALATION OF 2-METHYLPYRIDINE DERIVATIVES ETHYL 6-METHYL-PYRIDINE-2-ACETATE, 52, 75 Metalation, directed, 53, 59 Methallyl alcohol, with phenyl-mercuric acetate to yield 2-methyl-3-phenylpropional-dehyde, 51, 17 METHALLYLBENZENE, 52, 115 7r-Methallylnickel bromide, 52, 115... [Pg.61]

Phenylmercuric acetate, with methallyl alcohol to yield 2-methyl-3-phenylpropion-aldehyde, 51, 17 1-PHENYL-1,3-PENTADIYNE, 50,... [Pg.63]

Conversion of (S)-2-cyano-2-methyl-3-phenylpropionic acid (6) to (S)-a-methylphenylalanine (7) through the Hofmann and Curtius rearrangements followed by hydrolysis also proceed with nearly complete retention of configuration (equation 8). ... [Pg.799]

As described by von Braun,138 2-methyl-3-phenylpropionic acid (5.5 g) is dissolved in concentrated sulfuric acid (8 ml) and treated, dropwise at 40°, with a 10% chloroform solution of hydrogen azide (1.3 moles). When evolution of nitrogen ceases, the mixture is poured on ice, the chloroform is distilled off, and the amine is carried over in steam. Neutralizing the distillate with hydrochloric acid and evaporation give pure oc-methylphenethyl-amine hydrochloride (4 g, 73%), m.p. 146°. [Pg.1082]

In contrast, reaction of diethyl propionylphosphonate with lithium bis-(trimethylsilyl)amide (LiHMDS) at -78 °C gave the expected enolate as evidenced by its highly diastereoselective condensation with benzaldehyde, leading to the formation of 3-hydroxy-2-methyl-3-phenylpropionic acid (equation 91) " . An attempt was made to develop this concept to enantioselective aldol condensation. However, condensation of a cyclic chiral propionylphosphonamidate (31), synthesized from ( S)-A-isopropyl-4-aminobutan-2-ol, with benzaldehyde yielded 3-hydroxy-2-methyl-3-phenylpropionic acid in disappointingly low 47% e.e. (equation 92)... [Pg.696]

Hydroxy-3-phenylbutyric acid, A51.il 2-(p-Methoxyphenyl)propionic acid, Y5.7 2-Hydroxy-2-methyl-3-phenylpropionic acid,... [Pg.202]

Acetoxy-2-methyl-3-phenylpropionic acid methyl esters A 29.15, A 29.16 2-Phenylcyclohexylamines, A52,5, A52.il... [Pg.215]

P-Hydroxycarboxylic acids. Propionyldimethyl-/ r -butylsilane added dropwise at — 78° to a soln. of /-Pr2NLi in THF/hexane under N2, after stirring for 25 min benzaldehyde added in one portion, quenched after 2 min with aq. NH4CI, extracted, the crude adduct dissolved in methanol/30% H2O2/3 N NaOH, and the slurry stirred at room temp, for 20 min (2SR,3RS)-3-hydroxy-2-methyl-3-phenylpropionic acid. [Pg.405]

By heating 2-allyloxycarbonylamino-2-methyl-3-phenylpropionic add 1202 with oxalyl dichloride, the corresponding 4-benzyl-4-methyl-oxazoUdine-2,5-dione 1203 was formed [883]. [Pg.311]

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