4- Methyl-3-nitro-4,5-dihydro

Mit Propen wird ein Gemisch aus 5-Methyl-3-nitro- und 4-Methyl-3-nitro-4,5-dihydro-l,2-oxazol (95 5 12%) und mit Ethenyl-trimethyl-silan 3-Nitro-5-trimethylsilyt-4,5-dihydro-1,2-oxazol (20%)2 erhalten. 

Oxazol 4-Methyl-3-nitro-4,5-dihydro- -2-oxid E14b, 911 (aus to-Br — N02-Verb.)... 

Benzothiazole, 2-methyl-2-phenyl-2,3-dihydro-synthesis, 6, 325 Benzothiazole, 2-nitro-reactions, 6, 285 Benzothiazole, 5-nitro-nucleophilic attack, 5, 62 reactions... 

Furan, 2,3-dihydro-5-methyl-polymers, 1, 276 Furan, 2,3-dihydro-3-methylene- H NMR, 4, 577 Furan, 2,5-dihydro-2-methylene- H NMR, 4, 577 tautomerism aromaticity and, 4, 595 Furan, 2,5-dihydro-2-nitro-structure, 4, 550 Furan, 2,3-dihydroxy-tautomerism, 4, 37 Furan, 2,4-dihydroxy-tautomerism, 4, 37 Furan, 3,4-dihydroxy-tautomerism, 4, 37 Furan, 2,5-diiodo-nitration, 4, 602 synthesis, 4, 712 Furan, 3,4-diiodo-reactions, 4, 650 Furan, 2,3-dimethoxy-synthesis, 4, 625, 648 Furan, 2,5-dimethoxy-synthesis, 4, 648 Furan, 3,4-dimethoxy-cycloaddition reactions, 4, 64, 625 lithiation, 4, 651 reactions... 

H-1,2-Oxazine, 3,6-dihydro-6-(2-pyridyl)-mass spectra, 2, 529 2H-1,2-Oxazine, tetrahydro-synthesis, 2, 92 4H-l,2-Oxazine, 5,6-dihydro-pyrolysis, 3, 999 synthesis, 3, 1017 tautomerism, 3, 999 4H-1,2-Oxazine, 5,6-dihydro-3-methyl-metallation, 1, 484 4H-l,2-Oxazine, 5,6-dihydro-3-nitro-reactions, 3, 1000 6H-l,2-Oxazine, 3,5-diphenyl-stability, 3, 997 synthesis, 3, 1014... 

Quinolin-4-one, (R)( +)-2-methyl-1,2-dihydro-synthesis, 2, 422 Quinolin-4-one, 3-nitro-synthesis... 

Thiazolo[3,2-a]pyridinium salts, 3-carboxy-2,3-dihydro-8-hydroxy-8-methyl-desulfbrization, 6, 687-688 Thiazolo[3,2-a]pyridinium salts, 6(8)-nitro-2,3-dihydro-... 

Thiophene, 2-amino-3-cyano-5-phenyl-synthesis, 4, 888-889 Thiophene, 3-amino-4,5-dihydro-cycloaddition reactions, 4, 848 Thiophene, 2-amino-3-ethoxycarbonyl-ring opening, 4, 73 Thiophene, 2-amino-5-methyl-synthesis, 4, 73 Thiophene, 2-anilino-synthesis, 4, 923-924 Thiophene, aryl-synthesis, 4, 836, 914-916 Thiophene, 2-(arylamino)-3-nitro-synthesis, 4, 892 Thiophene, azido-nitrenes, 4, 818-820 reactions, 4, 818-820 thermal fragmentation, 4, 819-820 Thiophene, 3-azido-4-formyl-reactions... 

Uracil, 5-methoxy-6-methoxymethyl-2-thio-synthesis, 3, 134 Uracil, 1-methyl-aminolysis, 3, 91 synthesis, 3, 110 Uracil, l-methyl-5,6-dihydro-synthesis, 3, 110 Uracil, 6-methyl-3-phenyl-synthesis, 3, 110 Uracil, 3-methyi-2-thio-synthesis, 3, 112 Uracil, 6-methyl-2-thio-oxidation, 3, 94 Uracil, 5-nitro-... 

Tile same methodology as mentioned for the preparation of (9) was applied for the synthesis of 8-nitro-l,6-naphthyridines. Heating diethyl N- 3-nitropyridin-4-yl)aminomethylenemalonate (12) in diphenyl ether yields ethyl 8-nitro-l,6-naphthyridin-4(lH)-one 3-carboxylate (13) (63JCS4237, 30%) and acid treatment of 4-( y, y-diethoxypropylamino)-5-nitro-2-(/3,/3 -trifluoroethoxy)-pyridine (14) gives in a similar way 8-nitro-5-(/3, /3-triflu-oroethoxy)-l,2-dihydro-l,6-naphthyridine (15, 76%). Subsequent oxidation with chloranil, acid hydrolysis, and methylation with methyl iodide gives 8-nitro-6-methyl-l,6-naphthyridin-5(6H)-one (16,63%) (81JHC941). 

The nitration of l,2,5-selenadiazolo[3,4-/] quinoline 77 with benzoyl nitrate affords the 8-nitro derivative 78, whereas methylation with methyl iodide or methyl sulfate afforded the corresponding 6-pyridinium methiodide 79 or methosulfate 80, respectively (Scheme 29). The pyridinium salt 80 was submitted to oxidation with potassium hexacyanoferrate and provided 7-oxo-6,7-dihydro derivative 81 or, by reaction of pyridinium salt 79 with phenylmagnesium bromide, the 7-phenyl-6,7-dihydro derivative 82. Nucleophilic substitution of the methiodide 79 with potassium cyanide resulted in the formation of 9-cyano-6,9-dihydroderivative 83, which can be oxidized by iodine to 9-cyano-l,2,5-selenadiazolo [3,4-/]quinoline methiodide 84. All the reactions proceeded in moderate yields (81IJC648). 

Difluoro-3-methyl-8-nitro-7-oxo-2,3-dihydro-7//-pyrido[l,2,3- /e]-l, 4-benzoxazine-6-carboxylic acid was obtained from 8-unsubstituted derivative by treatment with KNO3 (99MI56). 

Carboxyl group of (-)-9-fluoro-3-methyl-7-oxo-10-[(3S)-3-(tert-butoxy-carbonylamino)pyrrolidino]-2,3-dihydro-7//-pyrido[l,2,3- 7e]-l,4-benzoxa-zine-6-carboxylic acid was converted into l-nitro-2-oxoethyl group in 45% yield by treatment with l,l -carbonyldiimidazole in boiling CFICI3 for 18h, then with MeN02 in the presence of KOr-Bu for another 18 h (96MI12). 6-(2,2-Diethoxycarbonyl)acetyl derivative formed from the aforementioned 6-carboxylic acid, when it was treated with l,l -carbonyldiimidazole in... 

Nitration of ethyl (3S)-3-methyl-10-(2,6-dimethyl-4-pyridyl)-7-oxo-2,3-dihydro-7//-pyrido[l, 2,3- fe]-1,4-benzothiazine-6-carboxylate gave 8-nitro derivative (OOMIPIO). 

Chemical Name 5-(2-fluorophenyI)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one... 

Chemical Name 8-Nitro-1,2-dihydro-2-(N-methyl-piperazin-1 -yl)methylene-6-(o-chloro-phenyl)-1 H,4H-imidazo-[ 1,2-a] [ 1,4] -benzodiazepin-1 -one methanesulfonate... 

Chemical Name 1,3-Dihydro-1 -methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one Common Name -... 

So liefert die Reduktion von Anthracen in Gegenwart von Methyl- oder tert.-Butylchlo-rid Alkyl-dihydro-anthracene4 und 4-Jod-l-nitro-benzol, in Gegenwart von Benzol rcduziert, 4-Niiro-biphenyl (in CH3CN, 20% d. Th.)2. Analog verhalt sich Toluol5. 

Methyl-3-athyl-5-[2-thiocyanato-propyl-(2)]- 102 (2-Nitro-vinyl)- 79 2-(3-Oxo-buten-yl)- 722 2-(3-Oxo-butyl)- 722 5 -Oxo-2-me tliyl -4,5 -dihydro- 22 7... 

Methyl-2-propyl-4,5-dihydro- 701 5-Methyl-2-(trimethylammoniono-methyl)-3-(4-chlor-3-nitro-phenyl)-4-athoxycarbonyl- 454 1 -Nitroso-4-methyl-2-phenyl-2,5-dihydro- 480... 

Amino-7-methoxy-2-methoxycarbonyl-3-phenyl-5,8-quinoxalinequinone 6-Amino-7-methoxy-l-methyl-2-oxo-3-phenyl-1,2-dihydro-5,8-quinoxalinequinone 3-Amino-6-methoxy-8-nitro-2-quinoxalinecarbo-nitrile 1,4-dioxide... 

CN (Z)-6-(2-chlorophenyl)-2,4-dihydro-2-[(4-methyl-l-piperazinyl)methylene]-8-nitro-l//-imidazo[l,2-a][ 1,4]benzodiazepin- 1-one... 

Treatment of 4-methoxy-3-nitrocoumarin 23 with hydrazine hydrate and methylhydrazine in ethanol at room temperature for 3 h gave 1,2-dihydro-5-(2-hydroxyphenyl)-4-nitro-3H-pyrazol-3-one 24a and l,2-dihydro-5-(2-hydroxyphenyl)-2-methyl-4-nitro-3H-pyrazol-3-one 24b in 70 and 51% yields, respectively. 

Compound 24a was also obtained in 17% yield by heating of 4-hydroxy-3-nitrocoumarin 27 [12] with hydrazine hydrate in ethanol. A similar reaction of 27 with methylhydraine in boiling ethanol did not afford 24b because of the decomposition of the starting coumarin. However, when 27 was treated with methylhydrazine at room temperature for 24 h without solvent, the ring-opened methylhydrazine adduct 28 (36% yield) and 1,2-dihydro-5-(2-hydroxyphenyl)-l-methyl-4-nitro-3H-pyrazol-3-one 26 (ll%yield) were... 

Methyl 5-methoxy-6,7-dimethyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate Methyl 5-methoxy-6,7-dimethyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate 1 -oxide Methyl 3-methoxy-2-quinoxalinecarboxylate 2-Methy l-3-( 1 -methylallyl)quinoxaline 2-Methyl-3-(2-methylallyl)quinoxaline 2-Methyl-3-methylaminomethylquinoxaline 5-Methyl-7-methylamino-8-nitro-2-phenylquinoxaline 5-Methyl-7-methylamino-8-nitro-3-phenylquinoxaline... 

Methyl 6-methyl-7-nitro-2,3-dioxo-l,2,3,4-tetrahydro-5-quinoxalinecarboxylate Methyl 4-methyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate 2-Methyl-3-( 1 -methylprop-1 -enyl)quinoxaline Methyl 3-methyl-2-quinoxalinecarboxylate... 

Bay K = methyl-l,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) pyridine-5-carbox-... 

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