Methyl n-valerate

Synonyms Methyl pentanoate Methyl n-valerate Methyl valerianate Pentanoic acid methyl ester Valeric acid, methyl ester... 

Lapp, Widnmann, 1915, 409, 143. l-Ammo-2 methyl-n-valeric Acid. 

L (4-) Isoleucine, a-amino- -methyl-n-valeric acid R — a-methyl-n-propyl (Al, N, NP, NI)... 

May be prepared satiriactorily from 2>methyl butanol through the intermediates, 2-methylbutyl bromide, 2-methylbutyronitrile and 3>methyl-n-valeric add by the method of Hass and Marshall (382). 

Fig. 10.4 Chromatogram of organic acids extracted from the same urine of the patient illustrated in Fig. 10.3, separated as their O-n-butyloxime and trimethylsilyl derivatives under the conditions described in the legend to Fig. 10.2. Peak identifications are 1, lactate 2, glycollate 3, unidentified 4, 2-hydroxy-n-butyrate plus 3-hydroxy-propionate 5, sulphate 6, 3-hydroxybutyrate and 3-hydroxyisobutyrate 7, 2-hydroxyisovalerate 8, 3-hydroxyisovalerate 10, 2-hydroxyisocaproate 11,2-hydroxy-3-methyl-n-valerate 12, phosphate 13,2-oxoisovalerate (peak 1) 14,2-oxoisovalerate (peak 2) 15, 2-oxo-3-methyl-/i-valerate (peak 1) 16, 2-oxo-3-methyl-n-valerate (peak 2) 17, 2-oxoisocaproate 18, citrate 19, 4-hydroxyphenyl-lactate 20, n-tetracosane (standard) 21, n-hexacosane (standard). The separation of O-n-butyloxime-TMS derivatives of the keto acids from the TMS-hydroxy acids and other components is apparent (compare with Fig. 10.3). Note the apparent loss of 4-hydroxyphenylpyruvate. (The horizontal axis represents the time elapsed in minutes from sample injection.)...

Fig. 10.5 Mass spectra of the ethoxime-trimethylsilyl derivatives of (a) 2-oxoisovaleric, (b) 2-oxo-3-methyl-n-valeric (peak 1), (c) 2-oxo-3-methyl-/i-valeric (peak 2) and (d) 2-oxoisocaproic acids and the trimethylsilyl derivatives of (e) 2-hydroxyisovaleric, (f) 2-hydroxy-3-methyl-rt-valeric and (g) 2-hydroxyisocaproic acids.

Position of 2-hydroxy-3-methyl-n-valeric and 2-hydroxyisocaproic acids. (Redrawn with modifications from Langenback etaly 1979)... 

METHYL-n-VALERIC-TMS-l NERVONIC-TMS-1 NICOTINIC-TMS-1 NONADECANOIC-TMS-1 NONANEDIOIC-TMS-2 (AZELAIC) NONANOIC-TMS-1 (PELARGONIC) OCTADECANOIC-TMS-1 (STEARIC)... 

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