Methyl lithium strength

An example of this type of calculation is the assay of Lithium Carbonate Tablets BP. Lithium carbonate is used as an antidepressant in 250 mg and 400 mg strengths. The BP assay is to weigh and powder 20 tablets. Add a quantity of the powder containing 1 g of lithium carbonate to 100 mL of water add 50 mL of 1 M hydrochloric acid and boil for 1 minute to remove carbon dioxide. Cool and titrate the excess acid with 1 m sodium hydroxide solution using methyl orange as indicator. The assay is then repeated omitting the sample. 

In comparison with sucrose, the sweetening strength of this compound is /sac, mol (0-25) = 1250. Hemandulcin is somewhat less pleasant in taste than sucrose and exhibits some bitterness. The racemic compound was synthesized via a directed aldol-condensation reaction by adding 6-methyl-5-hepten-2-one to a mixture of 3-methyl-2-cyclohexen-l-one and lithium di-isopropylamide in tetrahydrofuran, followed by chromatographic separation of ( )-hemandulcin (I, 95%) from the diastereomeric counterpart ( )-epihemandulcin (II, 5%). Whereas I is sweet, II exhibits no sweet taste. 

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