4-Methyl-3-hydroxythiazole-2-thione

Other thiohydroxamic acid derivatives have been used for the generation of radicals. Acyl derivatives of iV-hydroxythiazole-2-thione (75) have been explored by Barton as precursors for carbon radicals [86JCS(P1)39]. It has also been shown that similar precursors can be used for the generation of dialkylaminium cation radicals, N-hydroxy-4-methyl-thiazole-2-thione carbamates, TTOC carbamates 76 (91JOC1309). In contrast to... 

Thiazole A -oxides can easily be alkylated on the oxygen. For example, Ar-(alkoxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(377)-thiones were prepared from Ar-(hydroxy)-5-( -methoxyphenyl)-4-methylthiazole-2(3//)-thione tetraethylammonium salt and an appropriate alkyl chloride or tosylate in moderate to good yields <20060BC2313>. A -Methoxythiazole-2(377)-thiones were synthesized from the A -hydroxythiazole-2(3//)-thiones by treatment first with a tetraalkylammonium hydroxide in methanol and then methyl ra-toluenesulfonate in DMF <2005EJ0869>. 

Solubility soluble in many organic solvents (dimethylsulfox-ide, dimethylformamide, ethyl acetate, chloroform, dichloro-methane, benzene) slightly soluble in THE, methyl ferf-butyl ether, diethyl ether, and EtOH almost insoluble in water. Preparative Methods CPTTOH and a number of closely related derivatives thereof, such as 4-(/ -methox3q)henyl)-,4-(p-methylphenyl)-, 4-phenyl-, and 4-(/ -nitrophenyl)-substituted 7V-hydroxythiazole-2(3i thione, A-hydroxy-4-methylthia-zole-2(3//) thione (commercially available), and TV-hydroxy-4-methyl-5-(/>-methox) henyl)thiazole-2(377) thione are prepared from the corresponding a-haloketones in three synthetic... 

Related Reagents. A -Hydroxypyridine-2-thione 4-Methyl-3-hydroxythiazole-2-thione 5-(/ Methoxyphenyl)-4-methyl-3-hydroxythiazole-2-thione (Diacetoxyiodo)benzene AAHydroxy-phthalimide. 

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