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2- methyl ester protect phosphate groups

A d(5 -CCGp)—the 5 end of the trinucleotide is protected as the methyl ester, while the 3 end carries a phosphate group activated by the condensation... [Pg.154]

The 2-(acetoxymethyl)benzoyl-protective group (4,5,6) has initially been used in the synthesis of particularly base-labile backbone modifications, such as phosphate methyl esters or methylphosphonates [51, 52], again thymine remains unprotected. Cleavage is achieved by elegant intramolecular reaction within 90 min at room temperature by use of potassium carbonate in dry methanol (Fig. 11). [Pg.276]

The rapid aminolysis of cobalt(llI)-chelated glycine esters in aprotic solvents (Scheme 10 N4 = (en)2 or trien, R = Me, Et, R = H, CHR"C02Et) could be of value in peptide synthesis. The cobalt atom acts as both an N-protecting and an activating group. The synthesis of the chelated amino acid esters has presented some difficulties.207 A recent paper208 describes the use of methyl trifluoromethanesulfonate for the alkylation of chelated amino acids using dry trimethyl phosphate... [Pg.436]


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See also in sourсe #XX -- [ Pg.969 ]




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2- methyl phosphates

2- phosphates protect phosphate groups

5 -Phosphate group

Ester groups

Ester protecting groups

Esters, protection

Methyl ester group

Methyl group

Phosphate protecting groups

Phosphates, protection

Protection methyl esters

Protective groups esters

Protective groups methyl ester

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