Methyl acarviosin

S. Ogawa and D. Aso, Chemical modification of the sugar moiety of methyl acarviosin synthesis and inhibitory activity of eight analogues containing a 1,6-anhydro bridge,... 

Derivatives of istamycin B, including its 3-O-demethyl and various 2 -A -acyI and 7V-amidinyl derivatives, have been prepared in the search for compounds less toxic than the parent. Further analogues of 1,6-anhydro methyl acarviosin have been synthesized, particularly 2 -substituted compounds (OH->NH2,F). ... 

Several 1,4-imino-linked carbadisaccharides containing 2-amino-2-deoxy-5a-carba-glucopyranosyl residues as analogues of the potent a-glucosidase inhibitor, acarviosine have been prepared, and the preparation of a manwo-configurated (1 ->6)-imino-linked unsaturated derivative using the reaction of methyl 6-amino-6-deoxy-a-D-mannopyranose with epoxide 112 has been reported. 

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