3- Methy 1- pyridine

C7H7N03 2-hydroxy-6-methy pyridine-3-carboxylic acid 38116-61-9 28.40 1.2744 2 10818 C7H8N202 3,4-diaminobenzoic acid 619-05-6 92.67 1.2333 2... 

When the 5-phenyl derivative of 43 was used, a mixture of 3-(2-phenyl-2-chloroethyl)- and 3-(2-phenylvinyl)-8-methyl-4-oxo-4H-pyrido[l,2-a]pyri-midines was obtained. Depending on the conditions, reaction of 2-aminopyridines with 2-acetyl-4-chloromethylbutyrolactone (47) led to a variety of bicyclic products (48-54) (Scheme 2). - Reaction of 2-amino-pyridines with the acid chloride (55) yielded 4-oxo-4H-pyrido[l,2-a]pyri-midines (56) and traces of the amides of type 57. From 2-amino-6-methy -pyridine, only the amide (57 R = 6-Me) was formed. ... 

Methy(pyridine (7 Picohne) 143 1 506 0 957i 167 231 8-Resorcylic acid salt. 

Carbo -phenyl)-hydiazmo].2.6-di= methy. pyridin-c8rbonsSure- 3)- thylester 22. 571. 

Preparation of 11-Keto-6 -Methy progesterone 3,20-Bis-(Ethylene Ketal) A mixture of 5 g of 11-keto-6(3-methylprogesterone (Spero et al, 7. Am. them. Soc., 78, 6213 (1956)], 503 ml of benzene, 26 ml of ethylene glycol, and 0.152 g of p-toluenesulfonic acid monohydrate was stirred and heated under reflux for 22 hours while water was removed by means of a water trap. The reaction mixture was then cooled to 30°C, 0.4 ml of pyridine was added, and stirring was continued for 10 minutes. 

Preparation of S-Acetylsulfanilamido-S-Methy/isoxazole 0.9 gram of 3-amino-5-methyl-isoxazole in 5 cc of pyridine was allowed to react with 2.0 grams of acetylsulfanil chloride accompanied by the generation of heat. After about one hour, water was added to the reaction mixture and the crystal precipitated out was recrystallized from alcohol to give 2.5 grams of 3-acetylsulfanilamido-5-methylisoxazole, melting point (decomposition) 220° to 221°C. 

As previously discussed, solvents that dissolve cellulose by derivatization may be employed for further functionahzation, e.g., esterification. Thus, cellulose has been dissolved in paraformaldehyde/DMSO and esterified, e.g., by acetic, butyric, and phthalic anhydride, as well as by unsaturated methacrylic and maleic anhydride, in the presence of pyridine, or an acetate catalyst. DS values from 0.2 to 2.0 were obtained, being higher, 2.5 for cellulose acetate. H and NMR spectroscopy have indicated that the hydroxyl group of the methy-lol chains are preferably esterified with the anhydrides. Treatment of celliflose with this solvent system, at 90 °C, with methylene diacetate or ethylene diacetate, in the presence of potassium acetate, led to cellulose acetate with a DS of 1.5. Interestingly, the reaction with acetyl chloride or activated acid is less convenient DMAc or DMF can be substituted for DMSO [215-219]. In another set of experiments, polymer with high o -celliflose content was esterified with trimethylacetic anhydride, 1,2,4-benzenetricarboylic anhydride, trimellitic anhydride, phthalic anhydride, and a pyridine catalyst. The esters were isolated after 8h of reaction at 80-100°C, or Ih at room temperature (trimellitic anhydride). These are versatile compounds with interesting elastomeric and thermoplastic properties, and can be cast as films and membranes [220]. 

The reaction of 2-phenyl-1,1-dicyanoallyl anion 20 with Af-methy 1-2,2-dimethylpropionitrilinm ion in acetonitrile solution resulted in formation of enamine 21, which on heating undergoes a ring closure to pyridine 22 <96SC A(50)623>. 

DTBMP 2,6-di-fert-butyl-4-methy I pyridine TMG 1,1,3,3-tetramethylguanidine... 

Di-/m-butyl-4-methy I pyridine (3) is hindered, allows coupling of Fmoc-amino-acid fluorides with weak nucleophiles (see Section 7.12) and is best for minimizing the enantiomerizaton of Fmoc-Cys(tBu)-F (see Section 8.1) during its reaction with the hydroxyl group of a linker-resin. 

The ring closure of A/-ethyl-/V-(3,4-alkylenedioxyphenylamino)methy-lenemalonates (839) in polyphosphoric acid at 120-130°C for 30 min afforded linearly fused tricyclic pyridine-3-carboxylates (840) in over 90% yields (73JAP6479). 

Am ino-1-methy 1-6-phenyl irnidazo 4,5-b]pyridine (29 PhIP), usually the most abundant product of food-derived mutagens, is formed by heating creatine and phenylalanine at 200 °C200. This compound is modestly mutagenic in the Ames test, but is a potent carcinogen in rats and mice, causing breast and colon cancers. 

In order to obtain further insight into the mechanism of the Mannich-type reaction, sulfone IP and silyl enol ether derived from acetophenone were reacted in the presence HOTf or TMSOTf, which could be produced in the reaction medium when using Bi(0Tf)3-4H20 as catalyst. It appeared that these two compounds efficiently catalyze the Mannich-type reaction (Table 7, entries 2 and 3). The reaction does not occur in the presence of 2,6-di-/<7V-buty I-4-methyl-pyridine [DTBMP] (1.0 equiv. of lp, 1.3 equiv. of silyl enol ether, 0.5 mol% of Bi(0Tf)34H20, 1.5 mol% of 2,6-di-/c/V-buty l-4-methy I-pyridine, 22 °C, 20 h, 99% recovery of lp), which indicates that triflic acid is involved in the mechanism (Table 7, entry 4). 

Z-aminO 1 -methy 1 6 phenylimidazo [4,5-b]-pyridine 2 aminO 3,7,8 trimethylimidazo[4,5 f]quinoxaline 2 aminO 3,4,7,8 tetramethyl 3H imidazO [4,5 f]quinoxaline inoxaline 3 aminO l,4 dimethyl SH pyrid [4,3 b] indole (Trp P I) and 3 aminO l methyl 5H pyrido [4,3 b]indole induced mutagenesis. Metabolic activation was required for positive results b... 

HO, C6H5 s 67 konz. 0 4- (2,4-Dinitro-phen-yl)-2,2,6,6-tetra-methy 1-1,2,5,6-tetra-hydro-pyridin-l-oxyl 75 156-157 (Chloroform/ Cyclohexan) 7... 

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