2-Methy 1-2-propanol

Fig. 5.40 Water dissolved in the alcohol-rich phases as a function of trisodium citrate concentration in the salt-rich phases at 25 °C. Equilibrium compositions are expressed in moles of water in the alcohol-rich phase per kg of alcohol and moles of Na Cit in the salt-rich phase per kg of water. - ethanol [206], -1-propanol, - 2-propanol, - 2-butanol, - 2-methy 1-2-propanol [203]...

Higher Alcohols. The most abundant, volatile minor products of alcoholic fermentation are the higher alcohols or fusel alcohols. The most important are isoamyl (3-methyl-l-butanol), d-active amyl (2-methyl-l-butanol), isobutyl (2-methy 1-1-propanol), and n-propyl (1-propanol) alcohols. It is now recognized (4, 5, 6, 7) that these higher alcohols are formed by decarboxylation of particular a-keto acids to yield the corresponding aldehydes, and these in turn are reduced to the alcohols in a manner analogous to the formation of ethyl alcohol from pyruvic acid. 

Tetrakisfpa,-2-ami no-2-methy I propanol ato)tetrakis(p2-2.amino-2-methylpro-panolato)hexacopper(II) perchlorate, 3877... 

The alcohol mixture was distilled to remove the majority of methanol, ethanol, formaldehyde, acetaldehyde, and water. Remaining water was removed with the use of 3A molecular sieves. The composition of the alcohol mix after removal of most of the methanol and ethanol was as follows (2.9%) methanol, (1.9%) ethanol, (11.9%) n-propanol, (81.3%) 2-methy 1-1-propanol, (1.4%) 2-methyl-l-butanol, and (0.7%) other components. Attempts to remove the small amounts of residual methanol and ethanol using 4A molecular sieves were not successful. 

The title compound 81 is an antidepressant" acting by selective inhibition of serotonin uptake in presynaptic neurons. Synthesis of (S)-(+)-[18F]fluoxetine, 81, has been carried out100a (equation 46) by condensation of [18F]4-chlorobenzotrifluoride 82 with (S)-(-)-3-(methy-lamino)- -phenyl-1-propanol 83100b. 82 has been prepared1003 as outlined in equation 47. 

Table VI. Vapor-Liquid Equilibrium Data at 760 mm Hg Water (1)—Ethanol (2)-2-Methy 1-1-Propanol (3)...

Treatment of tt-methylstyrene oxide with ied-butylmagnesiuui chloride or plienylnaagneaium bromide has i een rcported M fo t[Pg.209]

El eliminations begin with the same unimolecular dissociation we saw in the S <1 reaction, but the dissociation is follow ed by loss of from the adjacent carbon rather than by substitution. In fact, the El and S l reactions normally occur together whenever an alkyl halide is treated in a protic solvent with a non-basic nucleophile. Thus, the best El substrates are also the best S l substrates, and mixtures of substitution and elimination products are usually obtained. For example, when 2-chloro-2-methylpropane is warmed to 65 °C in 80% aqueous ethanol, a 64 36 mixture of 2-methy]-2-propanol (S]vjl) and 2-methylpropene (El) results. 

Microwave irradiations of 2-amino-2-methy 1-1-propanol with A -acylbenzotriazoles in the presence of SOCla produced 2-substituted-2-oxazolines in 84-98% yields <04JOC811>. 

Fig. 8.4. Chromatograms of alcohol mixtures containing 90% water (A) by using a calcium carbide reactor and (B) without a reactor. Peaks (A) 1 = air 2 = acetylene 3 = methanol 4 = ethanol 5 = 1-propanol 6 = 2-methy 1-1-propanol 7 = 1-butanol (B) 1 = air 2 = methanol 3 = ethanol 4 = water 5 = 1 -propanol 6 = 2-methyl4-propanol. Reprinted with permission from ref. 17.

Chloro-2-methylpropane reacts with water in three steps to yield 2-methy)-2-propanol. The first step is slower than the second, which in turn is much slowei than the third. The reaction takes place slowly at room temperature, and the equilibrium constant is near 1. 

This compound has two equivalent CH3 groups, as indicated by the signal at 18.9 ppm. Its lowest field carbon is a CH2, and so the group —CH2O must be present. The compound is 2-methy 1-1 -propanol. 

When the UV spectrum of methyprylon in 2-propanol was scanned between 400 and 220 nm, one maximum and one minimum were observed. The maximum is located at 294 nm (e = 33) and the minimum at 353 nm. The spectrum shown in Figure 3 was obtained from a solution of 300.1 mg of methy-prylon/100 ml of 2-propanol (3). 

Equimolecular proportions of theophylline and 2-amino-2-methy -l-propanol are dissolved in water and the water is evaporated until crystallization is almost complete. The crystals are filtered off and dried. The product has a melting point of 254°-256°C, softening at 245°C. 

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