5- Methoxysalicylic acid

In 2002, Lett et al. published a convergent stereospecific synthesis of the resorcylic macolactone LL-Zl 640-2 (567) (Scheme 9.13) and hence hypothemycin (481) 382, 383). They started with the preparation of the three building blocks, 551, 555 (Scheme 9.11), and 564 (Scheme 9.12). Methyl ester 551 was produced from 4-methoxysalicylic acid (549) in four steps. Reaction of alkyne 552 with enantiopure (/ )-propylene oxide 490 afforded chiral alkyne 553, which then was converted into (Z)-vinyl iodide 555. 

Figure 1.4 UV-MALDI mass spectrum of myoglobin. Matrix DHBs (2,5-dihydroxybenzoic acid [2,5-DHB] plus 2-hydroxy-5-methoxysalicylic acid [MSA] 9 1 [w/w]). Wavelength, 337nm mass analyzer, reflectron TOF.

See under Gentiaio Aldehyde, 2 3-Dihydroxy-benzaldehyde, and Resorcyuc Aldehyde. Methoxysalicylic Acid. 

A series of nonpolar matrices were evaluated for the analysis of synthetic polymers and compared to that of conventional ones. Among substituted polycyclic aromatic hydrocarbons l,4-dihydroxy-2-naphthoic acid, 9-anthracenecarboxylic acid (9-ACA), and its mixtures with 5-methoxysalicylic acid ( super 9-ACA) provided better signal for analysis of synthetic polymers - poly(ethylene glycol), poly(propylene glycol), Jeffamine,... 

ESIPT in 5-Methyl- and 5-Methoxysalicylic Acid ESIPT in p-Aminosalicylic Acid and Its Derivatives ESIPT in ... 

Yoshioka, S. Caldwell, L. Higuchi, T. Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter. J. Pharm. Sci. 1982, 71, 593-594. Fasano, A. Budillon, G. Guandalini, S. Cuomo, R. Parrilli, G. Cangiotti, A.M. Morroni, M. Rubino, A. Bile-acids reversible effects on small intestinal permeability —an in vitro study in the rabbit. Dig. Dis. Sci. 1990, 55, 801-808. 

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