4-methoxyphenyl thiourea

Methoxyphenyl Thiourea Tellurium Thiocyanate2 Under an atmosphere of dry nitrogen a solution of 0.58 g (5 mmol) of thiocyanogen in 20 m/ of absolute methanol is mixed with a solution of 2.34 g (5 mmol) of bis[4-methoxyphenyl] ditellurium and 0.77 g (10 mmol) of thiourea in 50 ml of absolute methanol at — 10°. The resultant solution is stirred in the dark at — 10u for 5 hand then concentrated under vacuum at 20°. The concentrated solution deposits yellow crystals on cooling to — 10° yield 2.6 g (70%) m.p. 115C (dec.). 

In the paper, discussed above in terms of a systematic PXRD analysis of aromatic thiourea derivatives, the authors have also described structural characterization of five randomly selected thioureas directly from the powder diffraction data collected on a laboratory diffractometer [38]. Whereas the structure determination procedure readily gave reasonable crystal structures for three derivatives, the ambiguities with two other structures (A-(4-fluorophenyl)-lV -isopropylthiourea (53) and W-(4-chlorophenyl)-iV-(4-methoxyphenyl) thiourea (54)) could not have been... 

The CP-MAS ssNMR spectra of (a) A/-(4-fluorophenyl)-A/-isopropylthiourea (53) and (b) A/-(4-chlorophenyl)-A/-(4-methoxyphenyl)thiourea (54). In both cases, no peak splitting is observed, indicating the presence of one thiourea molecule in the respective asymmetric units Z = 1). 

The IR spectrum of tetrakis(pyrazole)bis[l,2-benzisothiazolyl-3-olato-l,1-dioxide]-copper(II) shows that the o-sulfobenzimide fragment is solely in the deprotonated form." CuL, where L = AT-benzoyl-A/ -2-nitro-4-methoxyphenyl-thiourea, has an IR spectrum showing that there is a polymeric structure, with L coordinated through N, O and S atoms." " The IR spectrum of Cu(IBAB)2(N03)2, where IBAB = isonicotinamido-4-bis(2-chloroethyl)aminobenzaldimine, show ligand coordination via carbonyl O and azomethine N atoms." ... 

By interaction of 7-amino-8-oxo-3-vinyl-5-thia-l-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester with 4-bromoacetyl bromide was prepared 7-(4-bromo-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-l-azabicyclo (4.2.0)oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. The active methylene group in that product was then nitrosated with sodium nitrite. The initial product spontaneously tautomerizes to afford 7-(4-bromo-2-hydroxyimino-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-l-azabicyclo(4.2.0) oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. By the reaction of that compound with thiourea and then with trifluoroacetic acid was obtained (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-l-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium nitrite, (Z)-oxime (Cefdinir sodium nitrile). 

Bis[4-methoxyphenyl] tellurium oxide was reduced to bis[4-methoxyphenyl] tellurium by thiourea dioxide in a two-phase system consisting of 2 molar aqueous sodium hydroxide solution and petroleum ether (30-60°)2. 

Bis[4-methoxyphenyl] tellurium trichloroacetimidc was similarly reduced by thiourea in acetonitrile. Bis[4-methoxyphenyl] tellurium was isolated in 92% yield3. 

Phenyl, 4-methoxyphenyl, and 4-ethoxyphenyl tellurium thiocyanates are known only in the form of their complexes with thiourea ethylenethiourea, triphenylarsine oxide, 3-methylpyridine, 3-methylpyridine A -oxide, or 4-methylpyridine A -oxide. These compounds were prepared from the diaryl ditellurium compounds, thiocyanogen, and the ligands. ... 

L = Dihexylsulfoxides trimethylamine l,eu-diaminoalkane(n = 2-4) l,2-bis-(dimethylamino)ethane. tet a lethylpiperid ne pyridine, 4-methyIpyridine 2-methylpyridinc, pyridine 1-oxide 2-, 3-. and 4-methylpyridine 1-oxides triphenylphosphane triphenylphosphane oxide, sulfide, and selenidc " tributylphosphane selenide , tris[4-methoxyphenyl]phosphane selenide, 1,2-bis(diphenylphosphano)ethane f -diselenide, thiourea, letramethylthiourea, dithioxamide dimethylacetamide ... 

The best preparative method for mercaptopyrimidines varies from position to position from thioureas and their equivalents. Thiones in any of the electrophilic positions are prepared by thiolysis of halo-pyrimidines, or commonly by thiation of pyrimidinones using phosphorus pentasulfide or, more recently, the superior Lawesson reagent 2,4-bis-/ -methoxyphenyl-l,3,2,4-dithiadiphosphetane 2,4-disulfide. Thiolysis in the 5-position requires a metal sulfide and a 5-bromide under vigorous conditions. Alternatively, pyrimidines substituted with strongly electron-donating substituents may be sulfonated, for example, by chlorosulfonic acid, in the 5-position with subsequent reduction to thiol. 

Pyrazine- and quinoxalinethiones have been synthesized by treatment of halogeno compounds with sodium or potassium hydrogen sulfide, sodium polysulfide, phosphorus pentasulfide, or thiourea . Pyrazinethiones are directly prepared by treating 2(177)-pyrazinones with Lawesson s reagent (2,4-bis(4-methoxyphenyl)-l,3,2,4-dithiadiphosphetane 2,4-disulfide) <83H(20)797>. They are also obtained by treatment of (4-methoxybenzylthio)pyrazines with mer-cury(II) acetate and successive reduction <93JCS(P1)15>. 

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