4-methoxyphenyl groups

Electrolysis 0.6-1.0 V, 3 h, DMF, H2O, NaC104. The related 4-trityl-aminophenyl and 4-methoxyphenyl groups were not cleanly cleaved. 

Another pyridazinone-derived inotropic agent with cAMP phosphodiesterase inhibitory activity is pimobendan [UD-CG-115-BS CAS 74150-27-9, (21)], which has been developed in Germany. In contrast to the imidazolyl-phenylpyridazinone CI-930 (16) discussed above, in pimobendan the imidazole nucleus (substituted at C-2 by a 4-methoxyphenyl group) is fused to the benzene moiety attached to C-6 of the 4,5-dihydro-5-methyl-3(2//)-pyri-dazinone system. 

This synthetic procedure (Scheme 8) begins with an N-protected amino acid, which is converted into the corresponding oxazolidin-5-one derivative. Oxazolidin-5-one derivatives are widely used as activated amino acid derivatives for coupling and other reactions.[301 The protected amino acid 38 is reacted with p-anisaldehyde in benzene and a catalytic amount of Tos-OH to give 39 the 4-methoxyphenyl group at C2 is necessary to counteract the electron-... 

Oxidative removal of the 4-methoxyphenyl group in 61, followed by oxidation and deprotection as for the synthesis of 55, gave the allyl glycoside (62) of the... 

These polymers exhibit a stable n-doping state in comparison to polymers with the 4-methoxyphenyl group instead of the crown ether subunit. 

Sc(OTf)3 (4 mol%)-catalyzed addition of 1-trimethylsilyl nitropropanate to aryl and alkylimines was described [109]. The use of N-(4-methoxyphenyl)imines gave superior yields and/or diastereoselectivities of P-nitro amines in most cases (72-99% yield, antijsyn = 5/3-9/1). The products could be reduced to 1,2-diamines by samarium diiodide reduction, formation of the cyclic urea and cleavage of the 4-methoxyphenyl group with ceric ammonium nitrate (CAN). This methodology was later employed for the synthesis of pseudo-C2-symmetric triamines as candidates for human immunodeficiency virus (HIV) protease inhibition [110]. 

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