Methoxy propoxy

Chemical name l-(2-Methoxy-propoxy)-propanol 2/ 1 -(2-Methoxy-methylethoxy)-propanol mixture... 

Methoxy-methylethoxy)-propanol 2 (2-Methoxymethylethoxy)-propanol METHOXY PROPOXY PROPANOL -83... 

Andrushko N, Andrushko V, Thyrann T, Kdnig G, Bomer A. Synthesis of enantiopure (R)-2-(4-methoxy-3-(3-methoxy-propoxy)-benzyl)-3-methylbutanoic acid-a key intermediate for the preparation of Aliskiren. Tetrahedron Lett. 2008 49(41 ) 5980-5982. 

Mention has already been made of the application of alkoxycyclophos-phazenes, [NP(OR)2] , as flame retardants in rayon. Although the methoxy-derivatives, with their high phosphorus content, were expected to be most efficient in this respect, their water solubility proved a major shortcoming. However, the n-propoxy series, [NP(OPr )2] ( mainly 3—6), were found to impart excellent flame resistance and were well retained by rayon. The cyclophosphazene alkoxides were obtained by the addition of sodium-n-propoxide to the chloride homologues, (NPCl2)n, and were added to the viscose dope before the rayon was spun. The flame resistance imparted by various amino- and thioalkoxy-derivatives was also tested, but found to be inferior to the results obtained with alkoxy-deriva-tives. Several patent applications have resulted from work on this topic. ... 

As predicted, the C2,C2 -isopropoxy and propoxy groups are more potent than the corresponding methoxy (0.8 and 1.5 pM vs. 6.4 pM). In addition, C3,C3 -substitution has an effect on both the potency and photopotentiation factor. Although the absorption at 670 nm was improved with C3 substitution, the potency against PKC decreased for analogs 90, 92, and 97. 

New types of acyclic nucleoside phosphonates (408-412) have been obtained using a multistep synthetic approach based on N-1, O- and S-alkylations of 4-and 2,4-substituted 6-hydroxy and 6-mercaptopyrimidines with diisopropyl 2-(chloroethoxy)methylphosphonate and (R) or (S) - [2-(diisopropylphos-phonyl)methoxy] propyl tosylate. Inhibitory activity against viruses of both the nucleoside phosphonates and the related phosphonic acids was investigated. It was found that the 6[2-(phosphonomethoxy)ethoxy]pyrimidines must bear an (unsubstituted) amino group concomitantly on both C-2 and C-4, or an amino on C-2 and an OH group on C-4, to display antiviral activity. Alkyl ethers are preferred over alkyl thioethers. The compounds of the 6-[2-(phos-phonomethoxy)ethoxy] and 6-[2-(phosphonomethoxy) propoxy]pyrimidine... 

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