4- Methoxy-3-nitroacetophenone,

Positions ortho to the methoxy 4-Methoxy-3-nitroacetophenone group are meta to the carbonyl. 

CCH3 Use only numbers 4-methoxy-3-nitroacetophenone or l-(4-methoxy-3-nitrophenyl)ethanone. 

A methoxy group is ortho, para-directing, and a carbonyl group is meta-directing. The open positions of the ring that are activated by the methoxy group in p-methoxyacetophenone are also those that are meta to the carbonyl, so the directing effects of the two substituents reinforce each other. Nitration of p-methoxyacetophenone yields 4-methoxy-3-nitroacetophenone. 

Flavanones. - A simple method of synthesizing 5,3 -dihydroxy-4 -methoxy-flavanone (165) has been described.3-Nitroflavanones have been synthesized by heating 2 -hydroxy-2-nitroacetophenone, benzaldehyde, and... 

Preparation by demethylation of 3-methoxy-2-nitroacetophenone with pyridinium chloride at 200° [2093]. 

Also obtained by demethylation of 2-hydroxy-5-methoxy-3-nitroacetophenone with 48% hydrobromic acid in the presence of red phosphorous at 85-90° for 16 h under argon atmosphere (90%) [2074]. 

Preparation from 4-hydroxy-3-methoxyacetophenone by nitration and subsequent demethylation of 4-hydroxy-3-methoxy-5-nitroacetophenone obtained,... 

Preparation by reaction of hydriodic acid with 3-methoxy-2-nitroacetophenone in the presence of phosphorous. Simultaneous demethylation and reduction of the nitro group occur [2093]. 

Preparation by reaction of stannous chloride on 2-hydroxy-6-methoxy-3-nitroacetophenone in refluxingconcentratedhydrochloricacid[2522,2523], (51%) [2523]. 

Obtained from 4-hydroxy-3-methoxy-2-nitroacetophenone rnru ether cleavage with aluminium chloride in a pyridine/1,... 

Obtained by methylation of 2-hydroxy-3-methoxy-5-nitroacetophenone with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone for 4 h (53%) [3955],... 

Obtained by reaction of bromine with 3-methoxy-4-nitroacetophenone in acetic acid [5965]. 

Draw the structure of each of the following compounds. If the name itself is incorrect, give a correct systematic alternative. (a) o-Chlorobenzaldehyde (b) 2,4,6-trihydroxybenzene (c) 4-nitro-o-xylene (d) m-isopropylbenzoic add (e) 4,5-dibro-moaniline (f) p-methoxy-m-nitroacetophenone. 

Acetophenone, methyl-/7-tolyl ketone p-chloroacetophenone, /7-bromoaceto-phenone, methyl -anisyl ketone, 2,4-di-methoxyacetophenone,2-methyl-4-metho-xyacetophenone, 5-methyl-2-methoxyace-tophenone, acetocumene, 2,5-trimethyl-acetophenone, 0-, m-, p-hydroxyaceto-phenone, 2,4-dihydroxyacetophenone, 3-methoxy-4-hydroxyacetophenone, o-nitroacetophenone, m-nitroacetopheno-ne, /7-nitroacetophenone, o-, m-, /7-ami-noacetophenone, 2-aceto-l -naphthoxy-acetic acid, 2-aceto-4-bromo-l-naphtho-xyacetic acid... 

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