Methods Used for the Study of Polymorphisms

Because of these differences in efficacy and toxicity, polymorphisms in drug metabolizing enzymes are of considerable importance to the pharmaceutical industry. Because of the possibility of increased drug toxicity or decreased efficacy in a proportion of the population, the development of a new drug may be impacted negatively if its metabolism is mediated via a pathway that is known to be polymorphic. This possibility is now always taken into account in the planning of metabolic studies and clinical trials. 

Polymorphisms are discovered by resequencing genes in known PMs or by resequencing a gene in a random set of the population. Verification of a polymorphism 

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