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Methods of Renal Preservation

Proponents of continuous hypothermic perfusion using colloidal solutions such as cryoprecipitated plasma (Belzer et td., 1972) claim that it provides better immediate life-sustaining function after transplantation. This is probably trae and it oflFers more potential for storage periods of 4 days or more. However, it is technically more diflicult to maintain sterility over such long periods, and its exprense and complexity makes it dependent on the availability of very skilled staff. [Pg.86]

However, although high potassium concentration was thought essential in early experimental work (Acquatella etcd., 1972), Fuller and Pe (1976) reported that potassium concentrations much higher than normal plasma levels led to poor renal function. A number of more recent studies have claimed that solutions containing high concentrations of sodium ions were equally or even more effective than those with high potassium (Moen et al., 1989 Sumimoto etal., 1989 Marshall etal., 1991). [Pg.86]

Toxic metabolites such as lactic acid and denatured proteins accumulate. The pH fells with accumulation of H ions (Green and Pe, 1979). [Pg.87]

The importance of iron in ischaemia-reperfusion injury through generation of ODFRs via the Haber-Weiss [Pg.88]

Although these data provided indirect evidence of iron involvement in ischaemia-reperfusion injury in kidneys and the combined administration of DFX and indomethacin had proved beneficial in actual survival experiments (Gower etal., 1989a), we still felt fhistrated by our inability to generate more direct evidence. At that time, information was just emerging that a small pool of intracellular iron was available in catalytic form as chelates [Pg.88]


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