Methionine sulfoximine glutathione synthesis

SELECTIVE INHIBITION OF THE SYNTHESIS OF GLUTAMINE AND GLUTATHIONE BY ANALOGS OF METHIONINE SULFOXIMINE... 

Compounds which inhibit the incorporation of cysteine into glutathione, such as methionine sulfoximine and o-glutamate, promote the evolution of H2S, suggesting that when cysteine-consuming processes are inhibited and the concentration of cysteine increases, sulfide is emitted as H2S (Rennenberg and Filner, 1982). Here again, a study of O-acetylserine synthesis under these conditions might yield some explanations. 

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