Methapyrilene

Methanol, l-isoquinolyl(phenyl)-confonnation, 2, 110 Methanol, pyrimidinyl-synthesis, 3, 113 Methanol, tetrahydropyran-2-yl-microwave spectra, 3, 625 Methantheline as neurotransmitter, 1, 175 therapeutic properties, 3, 882 Methaphenilene biological activity, 4, 911 Methapyrilene biological activity, 4, 911 toxicity, 4, 912 Methaqualone, 3, 150 as anticonvulsant, 1, 166 pyrido[2,3-d]pyrimidine analogues metabolism, 3, 205 as sedative, 1, 166 Metharbitone as anticonvulsant, 1, 166 Methazolamide... 

Resorting to alkylation chemistry again, 2-aminopyridine is condensed with the usual side chain halide to give diamine, 74. Alkylation of this with 2-chloromethylthiophene gives methapyrilene (75). Reaction with 2-chloromethyl-5-chlorothiophene affords the potent antihistamine chlorothen (76). ... 

Amino-1,3-propanediol lopamidol 2-Aminopyrazine Sulfalene 2-Aminopyridine Diphenpyramide Methapyrilene HCI Phenyramidol Pyrilamine Sulfadiazine Tripelennamine Zolimidine... 

Richardson FC et al. Dose responses in rat hepatic protein modification and expression following exposure to the rat he-patocarcinogen methapyrilene. Carcinogenesis 1994 15 325-329. 

Baker YA, Harries HM, Waring JF et al. Clofibrate-induced gene expression changes in rat liver a cross-laboratory analysis using membrane cDNA arrays. Environ Health Perspect 2004 112 428-438. Waring JF, Ulrich RG, Flint N et al. Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Environ Health Perspect 2004 112 439 48. 

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