Methanesulfonic acid esters

First the hydroxy group is protected as the TBS ether. In the second step lithium diisopropylamine (EDA) is used to deprotonate the a-carbon and the resulting lithium enolate is trapped as trifluoro-methanesulfonic acid ester. In the last reaction, palladium catalysis is used to introduce the carbon monoxide. In the presence of methanol this intermediate directly yields the methyl ester. 

Messenger-RNA mRNA) for gene cloning, 242 Mesylates. See Methanesulfonic acid, esters Metal organyls. See Organometallic compounds MethanaL See Formaldehyde Methanamine, 1,1-dimethoxy-jV.Mdiinethyi- formylation with, 82... 

Ihe azide Ig was prepared from the methanesulfonic acid ester of the initiator Ib. Nucleophilic displacement of the mesylate group by the azido anion in dimethylsulfoxide leads to the formation of the compound Ig obtained as a yellow oil after purification by column flash chromatography. The structures of the phenones Id-g are in correspondence with the results of the elemental analysis and the spectral data. 

Potassium cyanide potassium iodide Nitriles from methanesulfonic acid esters... 

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