Methadol metabolism

Oda, Y., Kharasch, E. D., Metabolism of methadone and levo-a-acetyl-methadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4) potential contribution of intestinal metabolism to presystemic clearance and bioactivation, J. Pharmacol. Exp. Ther. 2001, 298, 1021-1032. 

Pharmacokinetic properties Levomethadyl acetate is well absorbed from the intestinal tract and is extensively metabolized to various active metabolites, which contribute to the long duration of action. The metabolites nor-acytylmethadol, di-nor-acetylmethadol, nor-methadol, and methadol are formed by N-demethylation and hydrolytic cleavage of the ester bond (Moody et al., 1997)... 

The acetylation of some primary aliphatic amines such as histamine. mescaline. and the bis-N-demethylated metabolite of of-j-methadol" "" also has been reported. In comparison with oxidative deamination processes. N-acetylation is only a minor pathway in the metabolism of this cla.ss of compounds. 

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