Metals in Medicine Synthesis and Biological Reactivity

Metals in Medicine Synthesis and Biological Reactivity of the Platinum Anticancer Drug, c/s-Platin and its Isomer, trans-Platin 

I have no words of wisdom. .. I simply do my damndest (Barnett Rosenberg, 2005) 

In this set of experiments you will synthesize both cis- and trans-platin complexes and study their substitution kinetics in DMSO. The primary focus of the chapter is on c/.v-platin biological reactivity you will investigate the binding of c/.v-platin to DNA adducts by NMR and molecular mechanics methods and assess drug cytotoxicity using a Chinese hamster ovary (CHO) cell line. 

Integrated Approach to Coordination Chemistry An Inorganic Laboratory Guide. By Rosemary A. Marusak, Kate Doan, and Scott D. Cummings Copyright 2007 John Wiley Sons, Inc. 

In this exercise, you will synthesize both cis and trans forms of diamminedichloro-platinum(II) [Pt(NH3)Cl2], I and II, respectively (Fig. 6.1). These preparations represent a textbook example of the trans effect in inorganic chemistry. The trans effect refers to the labilizing effect one ligand (Li) has on another ligand, (L2) that is situated 180° from Lj. The frans-influencing series is shown below  

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