Metallo-azomethine ylides

Rh(l)-catalyzed [2-I-2-I-2] cyclotrimerization of 1,6-diynes (e.g., 1391 and 1394) with monoynes (e.g., 1392) in combination with stereospecific Ag(i)-catalyzed aldimine (metallo)azomethine ylide — cycloaddition cascades affords rapid access to complex heterocyclic benzene derivatives 1393 and 1395 in one-pot processes with the generation of five new bonds, four stereocenters and three rings (Schemes 266 and 267) <2000T8967>. 

Considering all of the previously mentioned advantages and the behavior of metallo-azomethine ylides, the catalytic enantioselective version was, undoubtedly, a very exciting area to explore. In a seminal work, Grigg and co-workers [26,27] employed a stoichiometric amount of the catalytic system... 

Although Grigg et al. (97) have been prolific authors in azomethine ylide chemistry, probably their greatest contribution has been in the development of metal-mediated technologies, leading to elegant solutions to the problems of regio-, stereo-, and enantiocontrol over reactions. Typically, EtaN or DBU deprotonation of amino esters, with subsequent metalation of the anion, led to the formation of stabilized, metallo-1,3-dipolar systems (340), often to the extent where isolation is possible (Scheme 3.115). 

Tsuge. Azomethine Ylide Cycloadditions via 1,2- Prototropy and Metallo-Dipole Formation from Imines, R. Grigg and V. Sridharan. Index. ... 

CONTENTS Facial Diastereoselection in Diels-Alder Cycloadditions and Related Reactions Understanding Planar Interactions and Establishing Synthetic Potential, A. G. Faille and Yee-Fung Lu. Substituent and Structural Effects in the Ozonolysis of Cyclic Vinylogous Esters. W. H. Bunnelle. N-Metalated Azomethine Ylides, S. Kanemasa and Otohiko Tsuge. Azomethine Ylide Cy-cloadditlons via 1,2- Prototropy and Metallo-Dipole Formation from Imines, R. Grigg and V. Sridharan. Index. 

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