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Metallic nanoparticles gene delivery

Advanced functional inorganic nanoparticles (NPs) have been studied intensively in the last couple of decades due to their unusual chemical and physical properties compared with their bulk materials, which enable them to be promising in applications as diverse as electronics,1 optics,2 optoelectronics,3 nanosensors,4 information storage,5 fuel cells,6 biomedicine,7 biological labeling,8 gene delivery,9 electrocatalysis,10 and surface enhanced Raman scattering (SERS).11,12 For instance, metal NPs with... [Pg.297]

Chitosan based self assembled/amphiphilic NPs plays a vital role in delivery of number of drugs, nucleic acids and metals. Recently, the effects of hydrophobic and hydrophilic modifications on gene delivery of amphiphilic chitosan based nanocarriers investigated and it has been observed that this type of modification allowed the improved gene delivery via amphiphilic nanoparticles [128]. It was reported that the chitosan-based self-assembled nanoparticles can be readily obtained by chemically attaching the hydrophobic moiety to the backbone of chitosan and its derivatives, as shown in Fig. 3.5. These self-assembled nanoparticles can circulate in the... [Pg.72]

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See also in sourсe #XX -- [ Pg.160 , Pg.161 ]



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