Metal phosphine anticancer activity

Bergmann D, Hinze J (1987) Electronegativity and Charge Distribution. 66 145-190 Berners-Price SJ, Sadler PJ (1988) Phosphines and Metal Phosphine Complexes Relationship of Chemistry to Anticancer and Other Biological Activity. 70 27-102 Bertini I, see Banci L (1990) 72 113-136... 

In addition to the release of carbon monoxide, transition metal carbonyl complexes have also found applications in anticancer chemotherapy [212], radiolabelling [213-216], and as photosensitisers. The cobalt complex shown in Fig. 14 a demonstrates a higher anticancer activity than cis-platin in certain mammary tiunor cells Hnes [217,218]. Complexes such as Tc-99m(I)(CO)3(OH2)3 along with hydroxymethyl phosphine derivatives [219] and the cyclopentadienyl complex shown in Fig. 14b have useful radiopharmaceutical applications, in diagnosis, using Tc, as the metal centre, and in therapy based on Re and Re isotopes [220]. 

There is increasing interest in the biological chemistry of phosphines and their metal complexes, Table 1. PH3 is a fumigant widely used against stored product commodities in many third world countries. Auranofin is a gold(I)phosphine complex which has recently been introduced into the clinic for treating rheumatoid arthritis. Auranofin also has limited antitumour activity in animals and this has lead to the discovery of other phosphines with broad spectrum anticancer activity. l,2-bis(diphenylphosphino)ethane (diphos) and its Au(I), Ag(I) and Cu(I) complexes are particularly effective. 

Anticancer Activity of Monodentate Phosphines and Their Complexes with Other Metals... 

---