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Metal-drugs protein interaction

However it would be a great mistake to believe that all actions of metal drugs will be at the DNA level. The metal complexes described here act in a highly selective manner with proteins — this is why they are used to provide heavy atom derivatives for crystallographic work. Thus we may expect that there will be other effects of the heavy metals which are associated with RNA and protein interactions. [Pg.46]

In this chapter, the key topics of artificial metalloproteins utilizing protein vacant space are reviewed, outhning recent studies since 2000. Section 3 shows the approaches for construction of the metal complex/protein composites and their crystal structures and, further, describes the interactions between metal-drugs and proteins. Section 4... [Pg.26]

Noncovalent interactions in metal complexes of biomolecules may play an important role in the creation of supramolecular structures around the metal center. For instance, extensive three-dimensional hydrogen-bonded stmcmres grow around metal complexes of barbiturates, recognized as the most widely used drugs for the treatment of epilepsy.Electrostatic interactions between a cation and the Trring of an aromatic molecule (cation-tt interactions) are common motifs in protein structures. Little is known about alkali and alkali-earth cation-tt inter-... [Pg.154]

Nonsteroidal antiinflammatory drugs, interaction with lithium, 36 66 No-phonon transition, 35 324 Norbomadiene complexes with cobalt, 12 286 with copper, 12 328, 330, 331 with gold, 12 348, 349 with group VIB metals, 12 231 with group VnB metals, 12 241 with iron, 12 265 with palladium, 12 314 with platinum, 12 319 with rhodium, 12 300-302 with ruthenium, 12 278, 279 with silver, 12 340-342, 344, 346 Norbomylsiloxane, 42 226, 228 Notch receptor proteins, 46 473, 475 h (N)" oxime complexes, osmium, 37 260 h (N,0) oxime complexes, osmium, 37 260 (NPr ljiFeCfrdto),], magnetization versus temperature, 43 230... [Pg.208]

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See also in sourсe #XX -- [ Pg.33 ]



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Drug-protein interactions

Drugs metals

Interaction metal-protein

Metal protein

Protein drugs

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