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Metal chelates antibody modification

The O-ECAT reagent is a superior alternative to the use of 2,4-dinitrophenylhydrazine (DNPH Chapter 1, Section 1.1) in the study of protein oxidation. DNPH modification produces detectable complexes, but it does not provide information as to what amino acids are involved. O-ECAT modifies carbonyl end products of protein oxidation and in addition, it can provide exact information as to the amino acids that were oxidized. Mass spec analysis of modified proteins performed after proteolysis gives the exact amino acid sequences including the sites of O-ECAT reagent modification. The same antibody that is specific for the metal chelate portion of the standard ECAT reagent also can be used to capture and detect the O-ECAT... [Pg.658]

The Chemical Modification of Antibody with Metal Chelates... [Pg.218]

See other pages where Metal chelates antibody modification is mentioned: [Pg.218]    [Pg.222]    [Pg.318]    [Pg.366]    [Pg.161]    [Pg.298]    [Pg.274]    [Pg.90]    [Pg.275]    [Pg.500]    [Pg.501]    [Pg.503]    [Pg.99]    [Pg.969]    [Pg.386]    [Pg.390]    [Pg.969]    [Pg.87]    [Pg.275]    [Pg.366]    [Pg.370]    [Pg.7114]    [Pg.420]    [Pg.376]    [Pg.273]   
See also in sourсe #XX -- [ Pg.218 ]



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