Metal-catalyzed Addition and Coupling Reactions

Trialkylboranes, including 9-alkyl-9-BBN, underwent cross-coupling with 1-alkenyl or aryl halides or triflates.750,751 The reaction was limitedly used for primary alkylboranes thus, hydroboration of terminal alkenes with 9-BBN was the most convenient to furnish the desired boron reagents in the presence of a base and PdCl2(dppf)750,751 or PdCl2(dppf)/2Ph3As (Equation (200)).752 [Pg.206]

Pd(PPh3)4 (10mol%) K2C03 (3 equiv.) dioxane-H20, reflux, 17 h 95% [Pg.208]

Alkenyl-alkenyl cross-coupling afforded stereodefined dienes, trienes, and further conjugated polyenes (Equation (203)). [Pg.208]

After the discovery of a cross-coupling reaction of arylboronic acids with aryl halides or triflates, numerous syntheses of natural and unnatural biaryls have been explored (Equation (204)). [Pg.208]

The biaryl coupling of arylboronic acid furnished a one-pot, two-step procedure for the synthesis of the angiotensin II receptor antagonist losartan 462, which played a critical role in the regulation of blood pressure,827 the AB biaryl ring of vancomycin aglycon 464, S/R= 1/1.3),828 bisporphyrin-based synthetic receptors 463 via a sequential double [Pg.208]

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