Metal binding anticancer agents

B. Metal-Binding and Metal-Based Anticancer Agents... 

The Pt anticancer agents and other potential therapeutic properties drive interest in complexes of these nonbiological metals with nucleic acids. In addition to standard nucleobase coordination modes, the heavy metals can facilitate deprotonation of and bind to exocyclic amino groups. Coordination compounds of Ru, Rh, and Re have been used in the study of... 

Using electrochemistry, uv-visible absorption, esr, and C nmr spectroscopy, and with the help of three new bleomycin analogues, the Fe(II) and Fe(III) binding sites of the antitumor antibiotic bleomycin have been located. The drug appears to utilize the amine-pyrimidine-imidazole region for iron binding. The physical properties of the metal complexes and how those properties relate to the proposed mechanism of action of the anticancer agent is also discussed. 

The synthetic octadentate ligand in Figure 13-3 is being evaluated as an anticancer agent. This chelate binds a metal through four N atoms and four O atoms. The chelate is covalently attached to a monoclonal antibody, which is a protein produced by one specific type of cell in response to one specific foreign substance called an antigen. In this case, the antibody binds to a specific feature of a tumor cell. The chelate carries a short-lived radioisotope such as or which delivers... 

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