Metal and metalloid-linked substituents

Several 3-substituted 6-methylmercuriothiopyridazines and complexes of perfluoro-pyridazine with metal carbonyl anions have been prepared 67MI21200). 

Pyridazines form complexes with iodine, iodine monochloride, bromine, nickel(II) ethyl xanthate, iron carbonyls, iron carbonyl and triphenylphosphine, boron trihalides, silver salts, mercury(I) salts, iridium and ruthenium salts, chromium carbonyl and transition metals, and pentammine complexes of osmium(II) and osmium(III) (79ACS(A)125). Pyridazine N- oxide and its methyl and phenyl substituted derivatives form copper complexes (78TL1979). 

4-Isoxazolyl Grignard reagents react normally in that a 4-carboxylic acid or 4-methanol can be obtained by reaction with CO2 or ketones (63AHC(2)365). Lithiation of 3,5-disub- 

Reaction of l-trimethylsulfonyl-5-trimethylsilylpyrazole with electrophiles affords 1-trimethyl-sulfonyl-5-substituted pyrazoles (for instance, R = CH(OH)R) 91CB1639 . The synthetic utility of 

5-trimethylsilylpyrazoles to prepare the corresponding bromo, iodo, carbinols, and ketones has been examined 84JOC4687, 91CB1639 . Preparation of 4 (or 5) substituted pyrazoles (iodo, acyl, or aryl substituents has been achieved from l-phenyl-4- or 5-stannylpyrazoles 92H(33)813 . 

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