Metal Alkyls Aryls, and Hydrides

Metal alkyls tend to be polarized especially for electropositive metals, 

A very useful feature of the deprotonation route is that heleroatoms on the substrate can bind the organolithium reagent and direct the deprotonation to the ring C—H bond ortho to the heteroatom. For example, —OMe, —CONMea, -NMe2, -SC Me, and even —F substituents on a benzene ring act in diis way  

Organolithium reagents and aryl bromides and iodides readily undergo metal-halogen exchange by nucleophilic attack of R on the halide (Eq. 14.4). This very rapid reaction is often carried out at very low temperature (—80°C) where other processes do not compete. 

The following are some of the numerous classical reactions of Grignard reagents  

An alternative pathway via a single-electron transfer mechanism has also been invoked in some cases (Eq. 14.10). Chiral auxiliaries such as biiuqihthols can make Grignard and related reactions asymmetric  

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To find the reason for the instability of simple transition metal alkyl, aryl, and hydride derivatives. 

METAL ALKYLS. ARYLS. AND HYDRIDES AND RELATED vBONDED LIGANDS... 

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