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Metabolites in safety testing MIST

From the perspective of the pharmaceutical industry, the attention given to metabolites started to increase when the Pharmaceutical Research and Manufacturers of America (PhRMA) commissioned a review of the role of metabolites in dmg induced toxicity. This group, called the metabolites in safety testing (MIST) committee, partnered with the U.S. Food and Drug Administration, convened several... [Pg.54]

Smith, D.A. and Obach, R.S., Metabolites in safety testing (MIST) Considerations of mechanisms of toxicity with dose, abundance, and duration of treatment, Chem. Res. Toxicol., 22(2), 267, 2009. [Pg.186]

Smith, D. A. and Obach, R. S. (2005). Seeing through the mist abundance versus percentage. Commentary on metabolites in safety testing. Drug. Metab. Dispos. 33(10) 1409-1417. [Pg.80]

Smith DA, Obach RS, Williams DP, Park BK. Qearing the MIST (metabohtes in safety testing) of time The impact of duration of administration on drug metabolite toxicity. Chem Biol Interact 2009 179(1) 60 67. [Pg.251]

See other pages where Metabolites in safety testing MIST is mentioned: [Pg.186]    [Pg.297]    [Pg.208]    [Pg.273]    [Pg.273]    [Pg.574]    [Pg.309]    [Pg.13]    [Pg.175]    [Pg.186]    [Pg.297]    [Pg.208]    [Pg.273]    [Pg.273]    [Pg.574]    [Pg.309]    [Pg.13]    [Pg.175]    [Pg.193]    [Pg.555]    [Pg.141]    [Pg.215]    [Pg.216]    [Pg.185]   


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Metabolite in safety testing

Mist

Safety testing

Safety tests

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