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Metabolite identification human ADME

At the early stage of compound selection and optimization for deciding a clinical candidate, drug metabolism studies are often conducted in vitro with liver fractions and in vivo with rats using nonlabeled compounds to define metabolic stability, soft-spot identification, CYP inhibition/induction potential, bioactivation or toxic metabolite formation, major in vitro metabolic pathways, and the limited in vitro interspecies comparison. Mass balance (or ADME) studies with collection of plasma in animals and humans using a... [Pg.574]

See other pages where Metabolite identification human ADME is mentioned: [Pg.157]    [Pg.159]    [Pg.272]    [Pg.574]    [Pg.155]    [Pg.174]    [Pg.369]    [Pg.485]    [Pg.158]    [Pg.375]    [Pg.153]    [Pg.501]    [Pg.597]    [Pg.195]    [Pg.883]   
See also in sourсe #XX -- [ Pg.158 ]



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ADME

Metabolite identification

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