Metabolism, xxviii

When metabolized, phenylbutazone yields two hydroxylated derivatives . The first is oxyphenbutazonc, the properties of which are described above the second contains an alcoholic hydroxyl group in the butyl side-chain XXVIII, R = (GH2)2-CHOHMe, R = Ph). This compound is devoid of anti-inflammatory activity but has enhanced uricosuric potency. Other derivatives with a modified side-chain show increased uricosuric activity associated with anti-inflammatory action. The most important are the phenylthioethyl analogue (G25671, XXVIII, R = (CH2)2-SPh, R = Ph) and its metabolite sulphinpyrazone (Anturan, XXVII, R = (CH2)2-SOPh, R = Ph). 

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