Metabolism relaxed phase

It has been postulated that 2-PAM exerts its cardiac action in rabbit atria through its alteration of calcium metabolism. The relaxation phase of skeletal muscle contraction seems to be directly affected by the sarcoplasmic reticulum because of its ability to sequester calcium actively.29,46 a similar role has been suggested for the sarcoplasmic reticulum in cardiac muscle. 6,83 The onset of muscle contraction takes place when calcium reaches a crit-cal concentration. This contraction is later reduced by the increased calcium-sequestering activity of the sarcoplasmic reticulum. Thus, 2-PAM can affect this process by decreasing the rate of calcium uptake by the sarcoplasmic reticulum, which results in increasing the time required to reduce the calcium concentration enough to allow relaxation to take place. This was demonstrated by the Increase in the relaxation phase. It was suggested that this... 

---