Metabolism Connecting Glycolysis to the Krebs Cycle

Intermediary Metabolism Connecting Glycolysis to the Krebs Cycle 

In 1948, Lipmann and his coworkers established the structure and the role of coenzyme A in its conversion to acetyl CoA (see the structure below), noting that the thioacetate linkage (-S-COCH3) is a high-energy linkage like the pyrophosphate linkage in ATP. The presence of pantothenic acid, one of the B vitamins, in the structure of coenzyme A (see the structure) explains its vital role in intermediary metabolism. For these 

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