Metabolism complex exposure problems

Metabolism New-onset diabetes mellitus is more common in hypertensive patients with abdominal obesity after short-term exposure to hydrochlorothiazide. Administration of hydrochlorothiazide 25 mg/day to 395 patients led to a 7-8% mean increase in fasting blood glucose and also more diagnoses of new-onset diabetes mellitus (13/ 195 versus 4/200) [9 ]. In a complex post hoc multifactorial analysis the problem was shown to occur particularly in those with abdominal obesity at baseline. 

---