Metabolic toxicology

Ekins S. In silica approaches to predicting metabolism, toxicology and beyond. Biochem Soc Trans 2003 31 611-4. 

Ekins, S. (2003) In silico approaches to predicting drug metabolism, toxicology and beyond. Biochemical Society Transactions, 31, 611-614. 

LameshRA. 1992. Polychlorinated biphenyls An overview of metabolic toxicologic and health consequences. Vet Hum Toxicol 34 256-260. 

Johanson, G. Filser, J.G. (1996) PBPK model for butadiene metabolism to epoxides quantitative species differences in metabolism. Toxicology, 113,40-47... 

The chemistry, biochemistry, metabolism, toxicology and structure-activity relationships have been comprehensively reviewed (B-74MI10701, B-73MI10701). 

Thomas, D.J. (2007) Molecular processes in cellular arsenic metabolism. Toxicology and Applied Pharmacology, 222(3), 365-73. 

Marks, F., Muller-Decker, K., and Furstenberger, G., A causal relationship between unscheduled eicosanoid signaling and tumor development cancer chemoprevention by inhibitors of arachidonic acid metabolism, Toxicology, 153, 11, 2000. 

R.K. Zalups and M.G. Cherian, Renal metallothionein metabolism after a reduction of renal mass. I Effect of unilateral nephrectomy and compensatory renal growth on basal and metal induced renal metallothionein metabolism. Toxicology 71 83-102, 1992. 

J. C. Dearden, Expert Opinion on Drug Metabolism Toxicology, 2007, 3, 635-639. 

Wolfgang GH, Gandolfi AJ, Stevens JL, and Brendel K. N-acetyl S-(l,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(l,2-dichlorovinyl)-L-cysteinein rabbit renal slices differential transport and metabolism. Toxicology and Applied Pharmacology 101 205-219,1989. 

Munro IC, Bernt WO, Borzella JF, et al. Erythritol an interpretive summary of biochemical, metabolic, toxicologic and chemical data. Food Chem Toxicol 1998 36(12) 1139—1174. 

Liver Primary rat hepatocytes, H4IIE (rat), HepG2 (human), or HepG2/ C3A (human) cells are generally used to study xenobiotic metabolism, toxicology, and liver function. 

Bergstrom, C.A.S. (2005) Computational models to predict aqueous drug solubility, permeability and intestinal absorption. Expert Opinion on Drug Metabolism Toxicology, 1 (4), 613-627. 

Ghersi-Egea. J.F.. Leininger-Muller. B.. Cecchelli. R.. and Fenstermacher. J.D. (1995) Blood-brain interfaces relevance to cerebral drug metabolism. Toxicology Letters, 82—83, 645—653. 

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