Metabolic arrest

Pharmacology Ethambutol diffuses into actively growing mycobacterium cells such as tubercle bacilli. It inhibits the synthesis of at least 1 metabolite, thus causing impairment of cell metabolism, arrest of multiplication, and cell death. No cross-resistance with other agents has been demonstrated. 

Hochachka, P.W. and M. Guppy (1987). Metabolic Arrest and the Control of Biological Time. Cambridge, MA Harvard University Press. 

Land, S.C., and P.W. Hochachka (1994). Protein turnover during metabolic arrest in turtle hepato-cytes role and energy dependence of proteolysis. Am. J. Physiol. 266 C1028-C1036. 

Hochachka, P.W., and M. Guppy (1987). Metabolic Arrest and the Control of Biological Time. Cambridge Harvard University Press. Hochachka, P.W., and P.D. Mottishaw (1998). Evolution and adaptation of the diving response Phocids and Otariids. In Cold Ocean Symposia, pp. 391 431, ed. H.O. Portner and R.C, Playle, Cambridge Cambridge University Press. Hochachka, P.W., and G.N. Somero (1984). Biochemical Adaptation. Princeton Princeton University Press. 

Hellemond JJ, Tielens AG (1997) Inhibition of the respiratory chain results in a reversible metabolic arrest in Leishmania promastigotes. Mol Biochem Parasitol 85 135-138... 

Doll CJ, Hochachka PW, Reiner PB. Effects of anoxia and metabolic arrest on turtle and rat cortical neurons. Am J Physiol 1991 260 R747-R755. 

Embryos of the brine shrimp Artemia franciscana are perhaps the quintessential example of an animal capable of acute metabolic arrest during... 

A second quiescent state in A. franciscana embryos that has been studied calorimetrically is anhydrobiosis, or life without water. These embryos are one of the most intensely studied anhydrobiotic systems (for reviews, see [119,120]), in part because their hydration state can be precisely controlled. Embryos enter a profound, yet reversible, state of metabolic arrest in response to cellular dehydration. While the metabolic transitions appear to be a function of water content, the controlling mechanisms involved are not fully understood. 

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