Meso-cyclopentenediol

The peptide-based phosphine ligand 105 was identified from a polymer-supported phosphine library of 75 members [154]. Enantioposition-selective desymmetrization of the meso-cyclopentenediol derivative 100 was promoted by a palladium complex of 105 to afford the cyclic carbamate 101 with 76% ee. This result demonstrated that the combinatorial approach is effective in the lead-generation stage of stereoselective catalyst development [155, 156]. The resin-supported palladium complex of Ac-D-Phg-Pro-D-Val-Pps-D-Leu-NH resin 106, which has also been developed through the combinatorial approach. 

Additional examples of desymmetrization of meso cyclopentenediol tosylcarba-mates. " ... 

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