Merulinic acid

Fungi Basidiomycetes Merulius T431 merulinic acids... 

Recently 2-keto-alkylresorcinols from wood-inhabiting basidomycetes have been demonstrated as the active components against 8 various cancer cell lines with IC50 values in the range from 6,9 to 63,9 pM [328]. These compounds inhibited the synthesis of both nucleic acids and proteins as demonstrated by the inhibition of the incorporation of labelled nucleotides and amino acids. Such results are in good agreement with those obtained earlier for merulinic acids by Gianetti et al. [43]. 

Merulius spp. Merulinic acids Anacardic acid 2-Hydroxy-6-[(Z)-heptadec-10-enyl]- cf.2 14 Europe... 

The ceriporiones are closely related to the antibiotic merulinic acids, e.g. merulinic acid-A (417), which have been isolated from fruit bodies of Merulius tremellosus and Phlebia radiata 275). 

The progressive development of functionality in the aromatic rings in the merulinic acids, the sarcodontic acids, and the ceriporiones is a strong indication of the close biogenetic connections between these metabolites of Aphyllophorales (Scheme 67). 

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