Merrifield, Bruce

University). In 1957, Merrifield became an assistant professor and in 1966 was appointed to the chair of biochemistry, a position which he held until his retirement in 1992. He was named John D. Rockefeller Jr. Professor in 1983 [B. Merrifield, Bruce Merrifield Life During a Golden Age of Peptide Chemistry The Concept and Development of Solid-Phase Peptide Synthesis, Oxford University Press, 1993 T. K. Sayer, Chem. Biol. Drug Design 2006, 67, 383]. 

Robert Bruce Merrifield (1921-2006) was born in Fori Worth, Texas, anti received his Ph.D. at the University oi California, Los Angeles, in 1949. He then joined the faculty at the Rockefeller Institute, where he remained until his death. In 1984, he was awarded the Nobel Prize in chemistry for his development of methods for the automated synthesis of peptides. 

R. Bruce Merrifield development of methodology for chemical synthesis on a solid matrix... 

In 1967, Bengt Lindberg was elected to the Royal Swedish Academy of Sciences and was a member of the Nobel committee for chemistry between 1974 and 1987. He presented the prize winners of 1979 (Herbert Brown and Georg Wittig) and the prize winner of 1984 (Bruce Merrifield). He received a number of Swedish awards for his scientific contributions, including the Celsius medal (1985). He was awarded the Haworth Memorial Medal from the Royal Society of Chemistry (1981) and was the first non-American to receive the Hudson Award from the American Chemical Society (1983). 

Prize in 1963 for inventing a new general method to synthesize important polymers, a method that uncovered much new basic science. A Nobel Prize in 1984 went to Robert Bruce Merrifield for his invention of a general approach to the synthesis of polypeptides and proteins, in a style directly reminiscent of the biological method used in such synthesis. 

An American biochemist, Robert Bruce Merrifield conducted research that revolutionized the way chemical synthesis is done in a variety of fields, including drug development. 

Combinatorial chemistry began with the work of Bruce Merrifield in 1963 to develop a solid-phase peptide synthesizer machine, which was recognized by the awarding of the Nobel Prize in Chemistry in 1984. All proteins are linear sequences... 

R. Bruce Merrifield Chemistry Solid-phase synthesis of peptides... 

Without a doubt, many of the above advantages were recognized in awarding the Nobel prize to Rockefeller University s Professor R. Bruce Merrifield for his seminal work on polymer-supported peptide synthesis.54... 

The amino group blocker is removed from the blocked peptide by mild hydrogenation, and the methyl ester group can be split by mild alkaline hydrolysis. The process of synthesizing large peptides and small proteins, pioneered by Bruce Merrifield, has been automated using a solid support medium rather than the classic organic synthetic procedure shown in Equation (4.13). The principle, however, remains the same. 

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