Merging Asymmetric Metal and Organocatalysis in Friedel-Crafts Alkylations

4 MERGING ASYMMETRIC METAL AND ORGANOCATALYSIS IN FRIEDEL-CRAFTS ALKYLATIONS 

The merging of metal catalysis and organocatalysis has recently emerged as a powerful tool to realize unprecedented multistep reaction sequences, one pot. Remarkable applications were also found in asymmetric synthesis [40], 

SCHEME 5.24 Binary catalytic system in the enantioselective alkylation of free phenols. 

SCHEME 5.25 Asymmetric Pictet-Spengler cyclization under relay binary catalysis. 

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