Mercapturic phenyl

Phenyl-mercapturic add Benzene Urine 9h No Traffic, combustion products... 

Boogaard, P.J. and Van Sittert, N.J., Suitability of S-phenyl mercapturic acid and lrans-lrans-muconic acid as biomarkers for exposure to low concentrations of benzene, Environ. Health Perspect. Suppl., 104, 1151-1157, 1996. 

There are quantitative differences in the benzene metabolites produced by different species (Sabourin et al. 1988). Fischer 344 rats exposed to 50 ppm benzene had undetectable amounts of phenol, catechol, and hydroquinone in the liver, lungs, and blood. The major water-soluble metabolites were muconic acid, phenyl sulfate, prephenyl mercapturic acid, and an unknown The unknown was present in amounts equal to the amounts of phenyl sulfate in the liver phenyl sulfate and the unknown were the major metabolites in the liver. B6C3Fj mice exposed to 50 ppm benzene had detectable levels of phenol and hydroquinone in the liver, lungs, and blood catechol was detectable only in the liver and not in the lungs or blood. As in the rat, the unknown was present in amounts equal to the amounts of phenyl sulfate in the liver. Mice had... 

Urine (S-phenyl-mercapturic acid Solid-phase extraction hydrolysis derivatization HPLC 1 mq/l NR Einig and Dehnen 1995... 

B), leading to an aromatic mercapturic acid. This is a frequent reaction of metabolically producedarene oxides (Fig. 13.5), documented for naphthalene and numerous drugs and xe-nobiotics containing a phenyl moiety. Note that the same reaction can also occur readily for epoxides of olefins (not shown in Fig. 13.32). 

Glycolate and glyoxylate also plasma and urinary ethylene glycol metabolites Excreted as sulfate and glucuronide conjugates. Other metabolites include catechol and hydroquinone. Urinary phenol excretion not a reliable indicator of benzene exposure. trans,trans-MA and S-phenyl mercapturic acid excretion have been used to assess exposure trans, trans-MA and phenol additional benzene metabolites... 

One of the compoimds commonly determined as its Phase 1 metabolite is benzene, whieh is metabolized to phenol in the body (see Chapter 23, Section 23.13 and Figure 23.16). The phenol metabolic product of benzene is measured in urine, usually by gas chromatography. The urine sample is treated with perchlorie aeid to hydrolyze phenol conjugates and the phenol is extracted into diisopropyl ether for ehromatographic analysis. Two other metabolic products of benzene, trans,trans-mueonie aeid and S-phenyl mercapturic acid, are now commonly measured as more-speeifie biomarkers of benzene exposure. 

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