2-Mercapto-4,5,6,7-tetrahydro

Mercapto-cthyl)-2-thiono-2,3-dihydro- 1025 2-Mercapto-5-methoxy- 882 2-Mercapto-6-inethoxy- 977 2-Mercapto-6-methyl- 977 2-Mercapto-6-methyl-4-nitro- 977 2-Mercapto-5-nitro- 873 2-Mercapto-4-nitro-6-trifluormethyl- 914 2-Mercapto-4,5,6,7-tetrachlor- 960 2-Mercapto-4,5,6,7-tetrahydro- 87 2-(2-Mercapto-1,3-thiazol-4-yl)- 77, 987 2-Methansulfonyl- 979 2-(Methoximino-methyl)- 938... 

Imidazol l,4-Dimethyl-2-mercapto-tetrahydro- IV/ld, 252 Pyrazolidin l,2-Dimethyl-4-... 

Furane 3,4-Diacetoxy-5-(fluoro-methylthio-methyl)-2-mercapto-tetrahydro- E10 (H - F)... 

Phenyl-l, 2,3,6-tetrahydro[l, 3]thiazino[3,2-n]quinolin-6-ones 90 were prepared in the reactions of 2-mercapto-5-phenyl-l,4-dihydroquinolin-4-ones 103 and 1,3-dihalopropane in 55-79% yields (97JAP(K)97/278780). 

Mercapto-3-methyl-4//-pyrido[],2-rz]pyrimidin-4-one and its 6,7,8,9-tetrahydro derivative were S-alkylated with 4-substituted benzylbromides (96EUP733633). 

Thiazolidine, 2,5-Dihydro- 1,3-thiazole, Tetrahydro-l,3-thiazine und 5,6-Dihydro- 1,3-thiazine werden durch Lithiumalanat6,7 und meist auch durch Natriumboranat7 zu den (w-Mercapto-aminen aufgespalten. 1,3-Thiazolidine lassen sich mit einem Lithi-umalanat-OberschuB ahnlich den 4,5-Dihydro-1,3-oxathiolanen zu Athylaminen wei-terreduzieren7,8 ... 

When the 3-thiourea derivative (59) was heated in boiling ethanol for 3 h, and then the evaporated reaction mixture was treated with 10% NaOH solution at 100°C for 20 min, anhydro 2-methyl-3-mercapto-4-hydroxy-5,6,7,8-tetrahydro[l,2-6]pyridazinium hydroxide (61) was obtained (71CPB159). The mercapto group was alkylated with benzyl bromide and was treated with HgCla in boiling ethanol to yield the 3-chloromercurithio derivative. Anhydro 3,4-dihydroxy-2-methyl-5,6,7,8-tetrahydropyrido[l,2-f ]pyridazinium hydroxide (62) was O-acylated with acetic anhydride, but the structure of the product was not elucidated (71CPB159). 

Das 5,6-Diamino-indol I kondensiert mit Thiophosgen zu 5,5(7,7) -Dimethyl-2-mercapto-6-oxo-1,5,6,7-tetrahydro-(pyrrolo[2,3-f benzimidazoiy (19% Schmp. > 300°). Das analoge Umset-zungsprodukt mit Phosgen selbst diirfte entgegen der Formulierung in Lit.215 als cyclischer, nicht aromatischer Harnstoff vorliegen215. 

Three compounds appear to be of particular importance in flavor volatiles identified by Ching (3) from beef diffusate or dried beef. These are 2-hydroxy-3-methyl-2-cyclo-penten-l-one, 4-hydroxy-5-methyl-3(2H)-furanone and 4-mercapto-5-methyl-tetrahydro-3-furanone. 

Benzylthio-2(177)-pyrazinone (1) gave 5-thioxo-3,4,5,6-tetrahydro-2(17/)-pyrazinone (3) (Na, liquid NH3, -76°C, 1 h 70%) a small yield of the intermediate 5-mercapto-2( I 7/)-pyrazinone (2) was obtained when the proportion of sodium to substrate was decreased.1565... 

Tetrahydro-lf/-l,3-diazepine-2-thiol (73), when heated with ethyl chloro-acetate, gives 74 while the reaction of 73 with chloroacetic acid in aqueous medium affords 3-(<5-aminobutyl)thiazolidine-2,4-dione (75) [Eq. (21)], via initial generation 74, followed by hydrolysis.94 Substituted 2-mercapto-imidiazolines undergo similar ring transformations.95-97... 

Recently, AEDA and SHA-0 yielded 41 and 45 odor active compounds for Scheurebe and Gewurztraminer wines, respectively (P). Ethyl 2-methylbutyrate, ethyl isobutyrate, 2-phenylethanol, 3-methylbutanol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, 3-ethylphenol and one unknown compound, named wine lactone, showed high flavor dilution (FD)- factors (Table I) in Gewurztraminer and Scheurebe wines. 4-Mercapto-4-methylpentan-2-one belongs to the most potent odorants only in the variety Scheurebe whereas cis-rose oxide was perceived only in Gewurztraminer (Table I). 4-Mercapto-4-methylpentan-2-one was identified for the first time in Sauvignon blanc wines (JO). The unknown compound with coconut, woody and sweet odor quality, which has not yet been detected in wine or a food, was identified as 3a,4,5,7a-tetrahydro-3,6-dimethylbenzofuran-2(3H)-one (wine lactone) (JJ). 

Imidazol 2-Mercapto-1-phenyl-tetrahydro- IV/Id, 252 IsothioharnstofT N-Benzyl-S-methyl-E4, 604 (aus dem Salz)... 

Benzoesaure 2-Mercapto-3-methyl-6-isopropyl- IV/la, 460 1-Benzothiophen 2-Ethoxycarbonyl-4,5,6,7-tetrahydro- E6a, 259 (2-C1 —1-CHO —cyclohexen + Na2S/Br —CH2 — COOR)... 

Imidazot 4-(3-Carboxy-propyl)-2-mercapto-1 -phenyl-tetrahydro-IV/Id, 252... 

Methoxy-2-methylthiazolo[4,5-Z>]pyrazine (3) refluxed with IN sodium hydroxide in methanol gave 2-amino-3-mercapto-5-methoxypyrazine (4) (805, 1011), and 3,2 5,6-bis[(l, 3-diethyl-2,4-dioxo-l, 2,3,4-tetrahydro)- , 4-pyrimidino]-pyrazine refluxed in ethanol with N sodium hydroxide for 2.5 hours gave 2,6-bis(ethylamino)-3,5-bis-A -ethylcarbamoylpyrazine (1169). 

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