Mephenesine

Ethanol (1) is the most widely used antianxiety agent. In the 1950s, the pioneering work of Berger on the muscle relaxant mephenesin [59-47-17, (71), led to the identification of meprobamate (24) as an effective agent for the treatment of anxiety. 

Mephenesin Crotonaldehyde Tilidine HCl Crotonyl chloride Crotamiton Cupric acetate... 

C3H7CIO2 96-24-2) see Chlorphenesin Diprophylline Doxofylline Guaifenesin Guanadrel lohexol lopydol Mephenesin... 

Potassium bromate can also be employed as an oxidizing agent in the assay of a number of pharmaceutical substances, namely mephenesin, phenol, and sodium salicylate. This particular method solely depends upon the formation of iodine monobromide (IBr) in relatively higher concentration of hydrochloric acid solution. 

Theory Mephenesin undergoes oxidation with bromine to yield a dibromo derivative as expressed in the following equation ... 

Procedure Weigh accurately 0.15 g of mephenesin and dissolve in 50 ml of DW into a 250 ml iodine-flask. Add to it 25.0 ml of 0.1 N potassium bromate solution and 10.0 g of powdered potassium bromide. After the dissolution of KBr, add 10 ml of hydrochloric acid, insert the moistened stopper, and after 10 seconds add 10 ml of potassium iodide solution. Titrate with 0.1 N sodium thiosulphate using starch solution as indicator. Each ml of 0.1 N potassium bromate is equivalent to 0.00911 g of C10H,4O3. 

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